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  1. No Access

    Chapter

    Antimicrobial Peptides

    The skin is traditionally viewed as a physical barrier to environmental insults. Its role in immunity goes beyond its role as simply a barrier, as it plays a dynamic role in regulating immune responses and con...

    Andrew J. Park BA, Jean-Phillip Okhovat MD… in Clinical and Basic Immunodermatology (2017)

  2. No Access

    Chapter

    Role of Reactive Metabolites in Drug-Induced Hepatotoxicity

    Drugs are generally converted to biologically inactive forms and eliminated from the body, principally by hepatic metabolism. However, certain drugs undergo biotransformation to metabolites that can interfere ...

    A. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams… in Adverse Drug Reactions (2010)

  3. No Access

    Chapter

    The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity

    Adverse drug reactions pose a significant public health problem. In some cases, the process of drug metabolism can contribute to the onset of toxicity through the bioactivation of a parent molecule to a chemic...

    Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham… in Adverse Drug Reactions (2010)

  4. No Access

    Chapter

    Genetic Markers for Differentiating Aspirin-Hypersensitivity

    The ingestion of acetylsalicylic acid (ASA) can induce allergic reactions such as ASA-intolerant asthma (AIA), ASA-induced acute or chronic urticaria/angioedema (AIAU or AICU), anaphylaxis, and, in rare cases,...

    Hae-Sim Park, Seung-Hyun Kim, Young-Min Ye… in Allergy Frontiers: Epigenetics, Allergens … (2009)

  5. No Access

    Chapter

    Lymphocyte Activation and the Family of NF-κB Transcription Factor Complexes

    NF-κB is a transcription factor complex known for some time to play a pivotal role in the regulated expression of a large number of genes which are activated during an immune response. Antigen in the context o...

    V. Bours, G. Franzoso, K. Brown, S. Park… in Mechanisms in B-Cell Neoplasia 1992 (1992)

  6. No Access

    Chapter and Conference Paper

    Antigen Society #33 Report (Public Epitopes)

    The purpose of this study was to identify operationally monospecific antibodies detecting alloepitopes shared by more than one HLA class I gene product (public epitope). In this Workshop, public epitopes are d...

    G. Rodey, P. Terasaki, M. S. Park, T. Fuller, D. Kostyu, D. Phelans… in Immunobiology of HLA (1989)

  7. No Access

    Chapter and Conference Paper

    Antigen Society #28 Report (DQw3)

    DQw3 (formerly MB3) is a DQ locus specificity that is found in strong linkage disequilibrium with DR4 and DR5. It is also found on some haplotypes, including DRw6, DRw8, DR2S (DB9), DR9, and the Bw57-DR7 haplo...

    B. D. Tait, M. S. Park, A. Barbetti, J. Langley, P. I. Teraski… in Immunobiology of HLA (1989)

  8. No Access

    Chapter and Conference Paper

    Antigen Society #32 Report (DP)

    HLA-DP is defined conventionally using primed lymphocyte ty** (PLT) cells. These PLT cells are of limited availability. Six DP alleles are recognized by the WHO Nomenclature Committee, and account only for a...

    A. H. Johnson, M. S. Park, J. G. Bodmer, L. Kennedy, S. Marsh… in Immunobiology of HLA (1989)

  9. No Access

    Chapter and Conference Paper

    Antigen Society #35 Report DQw4 [DQ “WA”])

    DQw4(DQ“WA”) is defined by a monoclonal antibody HU-46 (10W3101), which was established by immunizing C3H mice with EBV-WA line (A24-Bw54-Cw 1-DR4 DRw53-Dw15-DQ blank homozygous).

    A. Wakisaka, M. S. Park, A. Barbetti, T. Juji, P. I. Terasaki… in Immunobiology of HLA (1989)

  10. No Access

    Chapter and Conference Paper

    Analysis of Class II RFLP Patterns and T-Cell Clone Reactions

    From the data distributed at the Princeton Workshop, we have been able to distinguish many alleles of the alpha and beta chains of the DR, DQ, and DP loci. In addition, alleles of the pseudogenes of the DO, DN...

    Min Sik Park, Aida Barbetti, Toshinao Takenouchi, Paul I. Terasaki in Immunobiology of HLA (1989)

  11. No Access

    Chapter and Conference Paper

    Serologic Exercises of the Tenth Workshop

    The serologic exercises of the Tenth International Histocompatibility Workshop were conducted with the following goals:

    1. To produce a c...

    E. L. Milfor, M. S. Park, J.-M. Lalouel, L. J. Kennedy, E. J. Yunis in Immunobiology of HLA (1989)

  12. No Access

    Chapter

    Heterosexual transmission of HIV

    Since 1983 countries in the WHO European Region have taken part in the surveillance of AIDS in Europe by reporting their data to the WHO Collaborating Centre on AIDS. The cases of AIDS recorded fulfil the CDC ...

    Dr R. Ancelle-Park, Dr I. De Vincenzi in AIDS and Obstetrics and Gynaecology (1988)

  13. No Access

    Chapter and Conference Paper

    B Cell Precursors in Bone Marrow: In Vivo Proliferation, Localization, Stimulation by Activated Macrophages and Implications for Oncogenesis

    Precursor cells in mammalian bone marrow continuously give rise to virgin B lymphocytes by undergoing a series of genetic, mitotic and selection events (Osmond 1985, 1986, Osmond & Park 1987). During the diffe...

    D. G. Osmond, Y.-H. Park, K. Jacobsen in Mechanisms in B-Cell Neoplasia 1988 (1988)

  14. No Access

    Chapter

    Monoclonal Antibodies to Benzodiazepines

    Our interest in the brain benzodiazepine receptor (BZDR) is derived from both the social and neurobiological importance of the benzodiazepines (BZDs). The benzodiazepines (like diazepam or Valium) are the most...

    Angel L. De Blas, Dongeun Park… in Anti-Idiotypes, Receptors, and Molecular M… (1988)

  15. No Access

    Chapter and Conference Paper

    Antigen Report: HLA-DR3

    HLA-DR3, as originally described by the Leiden group in 1973, was clearly defined by high-quality sera at both the Seventh and Eighth International Workshops (WS).

    T. C. Fuller, M. S. Park, E. Thorsby in Histocompatibility Testing 1984 (1984)

  16. No Access

    Chapter and Conference Paper

    Antigen Report: HLA-Bw54, HLA-Bw55, and HLA-Bw56

    Heterogeneity of the antigen Bw22 has been reported at the previous Workshops and was confirmed in different populations by many investigators.

    Y. Konoeda, M. S. Park, A. Barbetti, A. Wakisaka… in Histocompatibility Testing 1984 (1984)

  17. No Access

    Chapter and Conference Paper

    Antigen Report: HLA-DQw1

    The supertypic specificity DR1 + 2 + w6 (later called DQwl = DC1 = MB1 = MT1 = LB12), was discovered at the Seventh Workshop [1]. This specificity was shown to reside on a subset of class II molecules called t...

    G. B. Ferrara, M. S. Park, N. Tanigaki, P. I. Terasaki in Histocompatibility Testing 1984 (1984)

  18. No Access

    Chapter and Conference Paper

    Human B Cell-Associated Antigens: Expression on Normal and Malignant B Lymphocytes

    Human B lymphocyte ontogeny and differentiation has been traditionally studied by the sequential expression of a series of B cell markers including heavy chain isotypes of immunoglobulin [1, 2], HLA-D-related ...

    L. M. Nadler, K. C. Anderson, M. Bates, E. Park, B. Slaughenhoupt… in Leucocyte Ty** (1984)