135 Result(s)
within
English
Biomedicine
**an Qi
Chapter
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Chapter
Screening and Clinical Verification of Extracellular Vesicle Biomarkers
Extracellular vesicles (EVs), lipid bilayer-encapsulated membrane particles carrying proteins, lipids, nucleic acids, and sugars, are shed by most cells into the extracellular milieu and function to mediate in...
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Ring Chromosome 17
Ring chromosome 17 (RC17) that replaces a normal chromosome 17 homologue is extremely rare, and only about 20 RC17 cases were reported in literature. RC17 is usually associated with deletion of the terminal re...
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Technologies for Visualization and Tracking of Extracellular Vesicles
Extracellular vesicles (EVs) are intercellular communicators that can deliver important biological molecules to recipient cells to participate in the regulation of pathophysiological processes. In recent years...
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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+ ions across the cellular membranes, but the physiological process...
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Synaptic Tagging in the ACC: Basic Mechanisms and Functional Implications
Synaptic tagging and capture (STC) is believed to play important roles in hippocampus-related associative memory. Recent studies in the anterior cingulate cortex (ACC), a key cortical region for pain and emoti...
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Renin-Angiotensin System and Cancer: From Laboratory to Clinics
Renin-Angiotensin System (RAS) is a vital system regulating blood pressure and maintaining sodium homeostasis in the human body. It consists of Angiotensin I (Ang I), Angiotensin II (Ang II), Angiotensin-conve...
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KDM7 Demethylases: Regulation, Function and Therapeutic Targeting
It was more than a decade ago that PHF8, KDM7A/JHDM1D and PHF2 were first proposed to be a histone demethylase family and were named as KDM7 (lysine demethylase) family. Since then, knowledge of their demethyl...
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Tuberculosis: Integrated Studies for a Complex Disease 2050
The authors of Tuberculosis: Integrated Studies for a Complex Disease were asked how they would see the future of their field 30 years later. This Chapter presents the authors’ views on the situation of tuberculo...
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Morphogenesis of Hepatitis E Virus
Hepatitis E virus, a leading cause of acute hepatitis worldwide, has been recognized as non-enveloped virus since its discovery in the 1980s. However, the recent identification of lipid membrane-associated for...
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Prions in the Environment
Scrapie and chronic wasting disease are two prion diseases of particular environmental concern, as they are horizontally transmissible. Prions are shed from diseased hosts in a diverse set of biologic matrices...
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Hepatitis E Virus
Since the sequence of hepatitis E virus (HEV) was determined from a patient with enterically transmitted non-A, non-B hepatitis in 1989, similar sequences have been isolated from many different animals, includ...
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Fundamentals and Biomedical Applications of Smart Hydrogels
Hydrogels are three-dimensional elastic networks containing a large amount of water formed from crosslinked hydrophilic polymer chains, which possess tunable tissue-like physicochemical properties. This chapte...
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Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression
Methylation of histone H3 lysine 9 (H3K9) is a repressive histone mark and associated with inhibition of gene expression. KDM3 is a subfamily of the JmjC histone demethylases. It specifically removes the mono-...
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Estimation of Microbial Mutation Rates in Tuberculosis Research
Antibiotic resistance is a dominant theme in tuberculosis research. Quantitative studies on microbial mutation rates play a key role in drug resistance research. Despite recent rapid advances in whole-genome s...
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Predicting the Disease Severity of Virus Infection
The COVID-19 pandemic has resulted in unprecedented burden on global health and economic systems, promoting worldwide efforts to understand, control, and fight the disease. Due to the wide spectrum of clinical...
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HDL and Lipid Metabolism
Mediating reverse cholesterol transport (RCT) is the most classic function of HDL. HDL and HDL-C participate in the entire process of RCT, including cholesterol removal from cells, cholesterol transport in cir...
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Dried Blood Spots in Therapeutic Drug Monitoring and Toxicology
In the quest for suitable surrogates to venipuncture and conventional (plasma and serum), dried blood spot ( ) has emerged as a very credible candidate with good analytical prospects. The use of for qual...
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Databases, Knowledgebases, and Software Tools for Virus Informatics
Virus infection is a common social health issue. In the past decades, serious virus infectious events have caused great loss in people’s life and the economics. The nature of rapid widespread and frequent vari...
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Entry Inhibitors of Hepatitis C Virus
Hepatitis C virus (HCV) infection affects approximately 1% of the world’s population and is a major cause of chronic liver diseases. Although antiviral therapy consisting of direct-acting antivirals (DAAs) can...
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Interaction Between Innate Lymphoid Cells and the Nervous System
The interaction between the immune system and the nervous system remains an intriguing enigma. Recent studies indicate that innate lymphoid cells (ILCs), a unique family of innate effector cells, participate i...
