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Dried Blood Spots in Therapeutic Drug Monitoring and Toxicology

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

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Abstract

In the quest for suitable surrogates to venipuncture and conventional biological matrices (plasma and serum), dried blood spot (DBS) sampling has emerged as a very credible candidate with good analytical prospects. The use of DBS for qualitative and quantitative purposes has garnered much attention from the scientific community over the past 60 years. This chapter details the applicability of DBS in therapeutic drug monitoring (TDM) and toxicology. Specifically, this chapter highlights topical issues including but not limited to the application of DBS sampling in pharmacokinetics (PK), toxicokinetics (TK), forensic toxicology, and biomonitoring of environmental contaminants. The strengths and weaknesses associated with its use, the various presumptions that need to be considered in the use of same for TDM, and other pertinent issues are herein addressed. Due consideration has also been devoted to discussing the implications of blood hematocrit variations (known as the hematocrit factor) and ways to tackle or cope with this pitfall. Finally, this chapter delineates the procedural steps in DBS sampling, recent innovations in DBS sampling, and high-throughput application of same.

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Authors and Affiliations

  1. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, Department of Pharmacognosy, China Pharmaceutical University, Nan**g, China

    Raphael N. Alolga, Qun Liu & Qi Lian-Wen

  2. Clinical Metabolomics Center, Department of Pharmacognosy, China Pharmaceutical University, Nan**g, China

    Raphael N. Alolga & Qi Lian-Wen

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  1. Raphael N. Alolga
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  2. Qun Liu
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  3. Qi Lian-Wen
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Correspondence to Raphael N. Alolga .

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  1. Department of Medical Pharmacology, University of Ghana Medical School, Accra, Ghana

    Seth Kwabena Amponsah

  2. USF Health Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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Alolga, R.N., Liu, Q., Lian-Wen, Q. (2022). Dried Blood Spots in Therapeutic Drug Monitoring and Toxicology. In: Amponsah, S.K., Pathak, Y.V. (eds) Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Springer, Cham. https://doi.org/10.1007/978-3-031-12398-6_4

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