147 Result(s)
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English
Biochemistry, general
Neurology
Neurosciences
Pharmacology/Toxicology
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Chapter
Conference Paper
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Chapter and Conference Paper
A Possible Relationship Between Folic Acid Neurotoxicity and Cholinergic Receptors in the Pyriform Cortex and Amygdala
The substantia innominata complex (SI) is the major source of cholinergic innervation to the amygdala, entorhinal and pyriform cortices, and the neocortex. Immunohistochemical studies using both monoclonal and...
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Chapter and Conference Paper
Tubocurarine, a Partial Agonist for Cholinergic Receptors
The mode of action of curare, a well-known competitive antagonist of acetylcholine at the nicotinic receptor, was examined with the single channel recording technique. Curare can open cholinergic channels in r...
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Chapter and Conference Paper
High-Resolution Radioautographic Study of Dopamine Binding Sites in the Rat Neostriatum Using 3H-Domperidone
The possibility to use the new ligand 3H-domperidone to identify some dopamine binding sites at the ultrastructural level was assessed in the neostriatum after in vivo administration and high-resolution radioauto...
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Chapter and Conference Paper
Cellular Mechanism Involved in the Synthesis of Cyclic GMP in Nervous Tissues
Intracellular cyclic GMP content responds to the stimulation of muscarinic receptor in a variety of tissues. Several aspects of the cellular mechanism involved in the synthesis of cyclic GMP were investigated....
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Chapter and Conference Paper
Studies on the Neurotransmitter Binding to Pig Brain Microvessels
Microvessels from pig brain areas were prepared by differential centrifugation techniques. These fractions were assayed for purity and structural unity by marker enzyme determination, light and electron micros...
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Chapter and Conference Paper
Energetics of Ligand Binding to Receptors
The primary events in the biological signals elicited by hormonal ligands are the initial binding of the ligands to their receptors and the consequent changes in the receptors that this induces. Although the e...
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Chapter and Conference Paper
Patch-Clamp Measurements of Elementary Chloride Currents Activated by the Putative Inhibitory Transmitters GABA and Glycine in Mammalian Spinal Neurons
Methods for measuring whole-cell and unitary Cl− currents in the soma membrane of cultured spinal cord neurons by the patch-clamp technique are described. To separate single channel Cl− currents activated by the ...
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Chapter and Conference Paper
Regulation of Noradrenergic Receptor Systems in Brain that Are Coupled to Adenylate Cyclase
The current status of regulation of norepinephrine (NE) receptor systems in brain that are coupled to adenylate cyclase is briefly reviewed. The availability of NE and the formation of the NE receptor complex ...
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Chapter and Conference Paper
Evidence That the D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland Is Associated with an Inhibitory Guanyl Nucleotide Component
Stimulation of the D-2 dopamine receptor in the intermediate lobe (IL) of the rat pituitary gland diminishes both basal and isoproterenol-stimulated adenylate cyclase activity. Cholera toxin increases IL adeny...
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Chapter and Conference Paper
Biochemical and Pharmacological Differentiation of Neuroleptic Effect on Dopamine D-1 and D-2 Receptors
In dopamine (DA) receptor binding tests two different receptor populations can be measured. By using 3H-haloperidol or 3H-spiroperidol as ligands D-2 receptors are detected. When the thioxanthene neuroleptics 3H-...
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Chapter and Conference Paper
(3,4-Dihydroxyphenylimino)-2-Imidazoline (DPI) and Its Action at Noradrenergic and Dopaminergic Receptors in the Nucleus Accumbens of Rats: Mesolimbic Catecholamine Receptors and Hyperactivity
Bilateral administration of ergometrine into the nucleus accumbens of rats pretreated 1–3 min earlier with intra-accumbens injections of noradrenaline, phenylephrine, clonidine and phentolamine has been found ...
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Chapter and Conference Paper
Multiple Opiate Receptors and Their Functional Significance
There is ample evidence from studies of peripheral isolated organs, binding of opiate receptor ligands to brain membranes and behavioural experiments that opiate receptors are not homogeneous but consist of di...
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Chapter and Conference Paper
Long-Term Adaptive Changes in Striatal Dopamine Function in Response to Chronic Neuroleptic Intake in Rats
Chronic neuroleptic drug administration to rats reverses initial dopamine receptor blockade so that animals exhibit striatal dopamine receptor supersensitivity. This effect may be of functional significance in...
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Chapter and Conference Paper
D2-Protein and D3-Protein as Markers for Synaptic Turnover and Concentration
The D2-protein is in the brain present on the external surface of neurones, especially in newly formed processes and in synapses. In olfactory bulb, where synaptogenesis occur at a high rate, the concentration...
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Chapter and Conference Paper
Dopamine Receptor Changes in Schizophrenia in Relation to the Disease Process and Movement Disorder
Although dopamine receptor antagonism probably accounts for the therapeutic efficacy of neuroleptic drugs in schizophrenia, there is little evidence to suggest that dopamine neurones are overactive (Bowers, 1974;...
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Chapter and Conference Paper
Brain Receptor Changes in Parkinson’s Disease in Relation to the Disease Process and Treatment
With regard to the behaviour of striatal D-2 receptors it was possible to divide parkinsonian patients into two subgroups, because either an increase or a decrease in the number of D-2 receptors was found. Dys...
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Chapter and Conference Paper
Pharmacological and Therapeutic Actions of GABA Receptor Agonists
GABA receptor agonists, e.g. progabide, modify the activity of several brain neuronal systems which are implicated in the pathogenesis of some neuropsychiatric disorders. Thus, alterations in noradrenergic and se...
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Chapter and Conference Paper
General Properties of 14C-L-Valine-Binding to Human Brain Tissue
L-Valine (VAL) binding is saturable, reversible, linear within a protein concentration of 0.2 to 0.8 mg prot./ml, pH dependent (pH-optimum 7.1 to 7.4), temperature dependent with extremely low binding at 0–4° ...
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Chapter and Conference Paper
Association of Proteins Irreversibly Labeled by 3H-Flunitrazepam with Different Benzodiazepine Receptors
Studies of the regional distribution of proteins irreversibly labeled by 3H-flunitrazepam indicate that the contribution of the individual proteins to total irreversible binding of 3H-flunitrazepam was different ...
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Chapter and Conference Paper
The Normal and Aberrant Development of Synaptic Structures Between Parallel Fibers and Purkinje Cell Dendritic Spines
Under normal circumstances the dendritic spines of the cerebellar Purkinje cell differentiate in association with the parallel fibers formed by the descending granule cells. In the adult these elements form th...
