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Physiological and cellular mechanisms of ischemic preconditioning microRNAs-mediated in underlying of ischemia/reperfusion injury in different organs
Ischemia–reperfusion (I/R) injury, as a pathological phenomenon, takes place when blood supply to an organ is disrupted and then aggravated during...
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Biopharmaceutical Evaluation of a Photoprotective Preparation Based on Melanin Isolated from Seed Episperm of Horse Chestnut (Aesculus hippocastanum L.)
The article focused on a study of the release of melanin from its gel dosage form and the toxicological properties of the gel. The recorded release...
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Microextraction Recovery of Tilmicosin Phosphate for HPLC-UV Determination in Washings from Surfaces of Pharmaceutical Equipment
A method for microextraction recovery and concentration of tilmicosin phosphate in washings from surfaces of pharmaceutical equipment for its...
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Development of a Peroral Dosage Form of a Nitrosyl Iron Complex with Thiosulfate Ligands, an Exogenous Nitric Oxide (NO) Donor
The composition and technology for obtaining a solid dosed stable dosage form of a promising representative of the class of nitrogen monoxide (NO)...
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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...
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Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission
Dietary salt is increasingly recognized as an independent risk factor for cognitive impairment. However, the exact mechanisms are not yet fully...
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Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: a double-blind randomized controlled trial
BackgroundThe regulation of the circadian clock genes, which coordinate the activity of the immune system, is disturbed in inflammatory bowel disease...
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The relationship between the functional movement screen and isokinetic muscle strength around the knee in different sports
The aim of this study was to determine objective data of the relationship between the Functional Movement Screen (FMS) and isokinetic muscle strength...
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Ultra-processed food consumption and risk of diabetes: results from a population-based prospective cohort
Aims/hypothesisUnderstanding the impact of the overall construct of ultra-processed foods on diabetes risk can inform dietary approaches to diabetes...
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Association between neutrophil to high-density lipoprotein cholesterol ratio (NHR) and depression symptoms among the United States adults: a cross-sectional study
BackgroundDepression acts as a noteworthy worldwide public health challenge. Identifying accessible biomarkers is crucial for early diagnosis and...
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Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice
BackgroundThe transition from childhood to adulthood, or adolescence, a developmental stage, is characterized by psychosocial and biological changes....
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC
Cardiac fibrosis is a commonly seen pathophysiological process in various cardiovascular disorders, such as coronary heart disorder, hypertension,...
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Management of orofacial pain starts with careful differentiation of odontogenic and non-odontogenic pain
The diagnosis and management of orofacial pain can be challenging, especially when pain of non-odontogenic origin mimics dental pain or is localised...
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Investigation of the Effects of Dimethyl Sulfoxide in Experimental Gout with Comparison of Dexamethasone and Indomethacin
Gout arthritis is an inflammatory arthritis characterized by increased serum uric acid and accumulation of monosodium urate (MSU) crystals in soft...
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Targeting Endothelial Progenitor Cells Reparative Potential Via Canonical Wnt/NOX-4 Signaling Pathway in Rats Dyslipidemia: Role of Resveratrol
Signaling pathways guiding the reparative function of endothelial progenitor cells (EPCs) are complex. Conflicts involve the double-face role of...
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Efficacy and Safety of Montelukast Sodium Tablets Combined with Budesonide Suspension in the Treatment of Patients with Bronchial Asthma
To evaluate the efficacy and safety of montelukast sodium tablets combined with budesonide suspension in the treatment of patients with bronchial...
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A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin
Lecithin is one of the most useful and valuable by-products of the oilseed industry and has long been a crucial component of a wide range of both...
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Design and Spectral Validation of RAD51 Inhibitors Based on BRC4 (1523-1546)
RAD51 is a core factor for homologous recombination to repair DNA double-strand breaks and overexpressed in breast cancer cells. Truncated peptide...
