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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
Helicobacter pylori ( H. pylori ) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high...
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The role of anti-citrullinated protein antibody in pathogenesis of RA
Rheumatoid arthritis (RA) is a common autoimmune rheumatic disease that causes chronic synovitis, bone erosion, and joint destruction. The...
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Hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis
BackgroundThe incidence of hypothyroidism following hemithyroidectomy and risk factors associated with its occurrence are not completely understood....
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Impact of DAA Treatment for HCV on Hepatocellular Carcinoma in a Predominately African American Population
PurposeThis study tested the hypothesis that our predominately AA medical center population would demonstrate a decline in HCV-driven HCC diagnosis...
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Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis
Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms....
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Sublingual sufentanil for patient-controlled analgesia during labor induction for pregnancy termination: an effective and well-tolerated approach
BackgroundEffective pain management during labor induction for pregnancy termination is essential. However, to date, no effective treatment has been...
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Robotic Left Pancreatectomy with Perirenal Tissue Excision and Left Adrenalectomy (Posterior Ramps) for Pancreatic Ductal Adenocarcinoma Abutting the Adrenal Gland
BackgroundRadical antegrade modular pancreato-splenectomy (RAMPS) has been largely described in left-sided pancreatic cancers.1.J...
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Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression
PurposeWhile comprehensive research exists on the mutation of the DNA repair gene BRCA1 , limited information is available regarding the clinical...
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Cholangiocarcinoma of the Middle Bile Duct: A Narrative Review
Resectable cholangiocarcinoma (CCA) arising from the middle of the extrahepatic biliary tree has historically been classified as perihilar or distal...
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Endoscopic ultrasound-guided hepaticogastrostomy vs. antegrade metal stent placement kee** an access route in patients with malignant biliary obstruction
BackgroundFew studies have compared endoscopic ultrasound (EUS)-guided hepaticogastrostomy (HGS) with EUS-guided antegrade metal stent placement...
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Normal ovarian sizes on MRI in pediatric patients: a preliminary study
BackgroundOvarian enlargement is one of several findings of pathology, including ovarian torsion. With increasing use of MRI for acute abdominal pain...
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Cost–utility analysis of a palliative care program in Colombia
BackgroundThe economic assessment of health care models in palliative care promotes their global development. The purpose of the study is to assess...
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Factors related to accurate clinicians’ prediction of survival: an international multicenter study in East Asia
PurposeRecent guidelines for prognostic evaluation recommend clinicians’ prediction of survival (CPS) for survival prediction in patients with...
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Deciphering glutamine metabolism patterns for malignancy and tumor microenvironment in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer characterized by metabolic reprogramming. Glutamine metabolism is...
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DNMT3A-R882: a mutation with many paradoxes
Understanding the underlying mechanism of acute myeloid leukemia (AML) has led to the discovery of novel biomarkers to help predict, treat and...
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Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia
PurposeT(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis....
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WT1 gene mutations impact post-transplant relapse in myelodysplastic syndrome with excess blasts 2 patients
Wilms tumor 1 ( WT1 ) gene mutations are infrequent in myelodysplastic syndrome (MDS), but MDS with WT1 mutations (WT1 mut ) is considered high risk for...
