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Investigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma
BackgroundOsteosarcoma (OS), the most common primary malignant bone tumor, predominantly affects children and young adults and is characterized by...
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Analysis of tumor abnormal protein expression and epidermal growth factor receptor mutation status in non-small cell lung cancer
BackgroundThe level of tumor abnormal protein (TAP) level has a significant impact on tumor growth, recurrence, and metastasis. Previous studies have...
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Novel associations between MTDH gene polymorphisms and invasive ductal breast cancer: a case–control study
ObjectiveTo reveal the contributing effects of MTDH gene SNPs in the risk of invasive ductal breast cancer (IDC).
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Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
BackgroundCholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1...
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Effects of the subtypes of apolipoprotein E on immune inhibition and prognosis in patients with Hepatocellular Carcinoma
PurposeTo investigate whether prognosis of patients with hepatocellular carcinoma (HCC) is affected by the abundance and subgroups of myeloid-derived...
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FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells
ObjectiveGlioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment outcomes. Cancer...
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Similar genetic profile in early and late stage urothelial tract cancer
IntroductionUrothelial tract cancer (UTC) ranks as the tenth most prevalent cancer and holds the seventh position in terms of mortality worldwide....
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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
Helicobacter pylori ( H. pylori ) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high...
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Chemotherapy’s effects on autophagy in the treatment of Hodgkin’s lymphoma: a sco** review
BackgroundClassical Hodgkin Lymphomas (HL) are a unique malignant growth with an excellent initial prognosis. However, 10–30% of patients will still...
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Mature B, T and NK-cell, plasma cell and histiocytic/dendritic cell neoplasms: classification according to the World Health Organization and International Consensus Classification
In 2022, two updated classification systems for lymphoid neoplasms were published by the World Health Organization (WHO Classification of...
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A cellular senescence-related signature for predicting prognosis, immunotherapy response, and candidate drugs in patients treated with transarterial chemoembolization (TACE)
BackgroundCellular senescence is essential to TME development, progression, and remodeling. Few studies have examined cellular senescence in HCC...
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Efficacy and safety of tislelizumab plus bacillus-calmette guérin with or without chemotherapy as a bladder-sparing treatment for high-risk non-muscle-invasive bladder urothelial cancer: a real-world study
BackgroundDespite adequate transurethral resection of the bladder tumor (TURBT) followed by intravesical bacillus-calmette guérin (BCG), high-risk...
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Endoscopic and exoscopic surgery for brain tumors
Nerves and blood vessels must be protected during brain tumor surgery, which has traditionally relied on microscopes. In the 2000s, endoscopes and...
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Hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis
BackgroundThe incidence of hypothyroidism following hemithyroidectomy and risk factors associated with its occurrence are not completely understood....
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Impact of DAA Treatment for HCV on Hepatocellular Carcinoma in a Predominately African American Population
PurposeThis study tested the hypothesis that our predominately AA medical center population would demonstrate a decline in HCV-driven HCC diagnosis...
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Comparison of synthesized and acquired high b-value diffusion-weighted MRI for detection of prostate cancer
BackgroundHigh b -value diffusion-weighted images (DWI) are used for detection of clinically significant prostate cancer (csPCa). This study...
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Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma
PurposeThe evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating advanced...
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Breast-conserving surgery versus modified radical mastectomy in T1-2N3M0 stage breast cancer: a propensity score matching analysis
PurposeBreast-conserving surgery (BCS) plus radiotherapy and mastectomy exhibit highly comparable prognoses for early-stage breast cancer; however,...
