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  1. No Access

    Article

    Oncogenic activation of the αPDGFR defines a domain that negatively regulates receptor dimerization

    The α platelet derived growth factor receptor (αPDGFR) extracellular Immunoglobulin (Ig) like domains 1 – 3 contain major determinants for ligand interaction. We now report that a deletion of Ig-like loop 3, b...

    Akyut Uren, ** Chen Yu, Musturay Karcaaltincaba, Jacalyn H Pierce… in Oncogene (1997)

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    Article

    Characterization of factor-independent variants derived from TF-1 hematopoietic progenitor cells: the role of the Raf/MAP kinase pathway in the anti-apoptotic effect of GM-CSF

    Human hematopoietic progenitor cells (TF-1) undergo apoptosis upon deprivation of their dependent cytokine. In this report, we have isolated and characterized some spontaneously derived cytokine-independent va...

    Jhy-Rong Chao, Chyi-Shyan Chen, Ting-Fang Wang, Li-Hui Tseng, Jaw-Ji Tsai… in Oncogene (1997)

  3. No Access

    Article

    Identification of p53 unbound to T-Antigen in human cells transformed by simian virus 40 T-antigen

    In several clones of SV40-transformed human cells, we investigated the relative amounts of large T-Antigen (T-Ag) and p53 proteins, both unbound and associated within complexes, with the goal of identifying ch...

    F J O'Neill, Y Hu, T Chen, H Carney in Oncogene (1997)

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    Article

    Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

    Dephosphorylation of the RB protein has been reported to be associated with apoptosis. In contrast, we show that treatment of HL60 cells with etoposide or cytosine arabinoside or treatment of breast epithelial...

    Wei-dong Chen, Gregory A Otterson, Stan Lipkowitz, Samir N Khleif, Amy B Coxon… in Oncogene (1997)

  5. No Access

    Article

    JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia

    Retinoid-induced proliferation causing hyperleukocytosis is a severe complication of retinoid therapy in t(15;17) acute promyelocytic leukaemia. The molecular basis of this phenomenon is unknown. It is possibl...

    E Duprez, J-H Tong, J Dérré, S-J Chen, R Berger, Z Chen, M Lanotte in Oncogene (1997)

  6. No Access

    Article

    Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells

    Postulated roles for p21Waf1/Cip1/Sdi1 (p21) in DNA repair and apoptosis remain controversial. Studies suggest both stimulatory and inhibitory effects of p21 in DNA repair. p21 has also been implicated in inducti...

    M Saeed Sheikh, Yong Q Chen, Martin L Smith, Albert J Fornace Jr in Oncogene (1997)

  7. No Access

    Article

    Map** of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu

    Overexpression of neu (also known as c-erbB-2 or HER-2) commonly occurs in human cancer and is also known to enchance tumor metastasis and chemoresistance. Our earlier reports showed that the adenovirus 5 E1A can...

    Hua Chen, Dihua Yu, G Chinnadurai, Devarajan Karunagaran, Mien-Chie Hung in Oncogene (1997)

  8. No Access

    Article

    The 96 kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation

    In the Xenopus egg and oocyte system, oncogenic Ras protein can induce cell cycle arrest. The effect of oncogenic Ras on the cell cycle seems to be mediated by the Raf – Mek – Erk pathway of Ras signal transdu...

    Bin-Tao Pan, Yong Zhang, Barbara Brott, Dong-Hua Chen in Oncogene (1997)

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    Article

    Failure of HPV E6 to rapidly degrade p53 in human HeLa×PNET cell hybrids

    The ability of the E6 protein from high risk human papillomaviruses (HPVs) to degrade p53 via the ubiquitin pathway plays a major role in the development of cervical carcinomas. We have previously generated ce...

    Jennifer S Isaacs, Pengchin Chen, Armandina Garza, Marc F Hansen… in Oncogene (1997)

  10. No Access

    Article

    Isolation of and effector for metastasis-inducing DNAs from a human metastatic carcinoma cell line

    Benign rat mammary epithelial cells transfected with restriction enzyme-fragmented DNA from a human malignant metastatic cell line (Ca2-83) produces transfectants that yield metastatic tumours in syngeneic rat...

    Haijuan Chen, Youqiang Ke, Adam J Oates, Roger Barraclough, Philip S Rudland in Oncogene (1997)

  11. No Access

    Article

    Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation

    Mer/Nyk/Eyk is an orphan receptor tyrosine kinase expressed at high levels in monocytes and cells derived from epithelial and reproductive tissues. Overexpression of Mer has been associated with lymphoid malig...

    Jian Chen, Kendall Carey, Paul J Godowski in Oncogene (1997)

  12. No Access

    Article

    Transcription factor AP2 is required for expression of the rat transforming growth factor-α gene

    DNase I footprinting of the rat TGFα promoter in the presence of crude cell nuclear extract revealed three sites of protein-DNA interaction (Fp-A, Fp-B, Fp-C) in the region from −222 to +73. Mutation of specif...

    Eugene A Berkowitz, Charles P Hecht, Jane C Azizkhan, **aorong Chen… in Oncogene (1997)

  13. No Access

    Article

    Myc represses the growth arrest gene gadd45

    The c-Myc protein strongly stimulates cellular proliferation, inducing cells to exit G0/G1 and enter the cell cycle. At a molecular level, Myc prevents growth arrest and drives cell cycle progression through t...

    Wilson W Marhin, Shaojun Chen, Linda M Facchini, Albert J Fornace Jr… in Oncogene (1997)

  14. No Access

    Article

    Transcriptional regulation of the hepatocyte growth factor (HGF) gene by the Sp family of transcription factors

    In this study, we have localized an enhancer element in the 5′-flanking region of the HGF gene promoter and have identified its functional transcriptional factors. Through transient transfection of NIH3T3 fibr...

    Jie-Gen Jiang, Qiuyan Chen, Aaron Bell, Reza Zarnegar in Oncogene (1997)

  15. No Access

    Article

    Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations

    To assess the effect(s) of the C-terminal domain on FGFR2 function, we engineered a series of mutant FGFR2 cDNAs encoding deletions in the C-terminus of the receptor and compared their growth properties in NIH...

    Matthew V Lorenzi, Paola Castagnino, Qiong Chen, Marcio Chedid, Toru Miki in Oncogene (1997)

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    Article

    Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

    Accelerated cellular repopulation has been described as a response of tumors to fractionated irradiation in both normal tissue and tumor systems. To identify the mechanisms by which cells enhance their prolife...

    R K Schmidt-Ullrich, R B Mikkelsen, P Dent, D G Todd, K Valerie, B D Kavanagh… in Oncogene (1997)

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    Article

    v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL

    We demonstrated previously that the activation of v-Abl protein tyrosine kinase (PTK) in IC.DP murine pre-mast cells resulted in suppression of apoptosis after withdrawal of interleukin 3 (IL-3), that protein ...

    Quan Chen, Jonathan Turner, Alastair JM Watson, Caroline Dive in Oncogene (1997)

  18. No Access

    Article

    Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide

    The exact mechanisms for the selective toxicity of chemotherapeutic drugs against tumor cells are not fully understood. We designed a series of experiments to test the possibility that the positive proliferati...

    Guan Chen, Junyan Shu, Dennis W Stacey in Oncogene (1997)

  19. No Access

    Article

    MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice

    FGF-1 is expressed in a high proportion of breast tumors. While overexpression of FGF-4 in the MCF-7 breast carcinoma cell line confers the ability to form spontaneously metastasizing tumors in ovariectomized ...

    Lurong Zhang, Samir Kharbanda, Denise Chen, Jamal Bullocks, David L Miller… in Oncogene (1997)

  20. No Access

    Article

    Characterization of human N8 protein

    We have shown before that the N8 mRNA is expressed at higher levels in lung tumor and lung tumor-derived cell lines than normal lung cells. In this paper, we have characterized the N8 protein, and studied its ...

    Shin-Lin Chen, **an-Kui Zhang, Douglas O Halverson, Mee Kyeong Byeon… in Oncogene (1997)

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