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  1. No Access

    Article

    Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC

    Aberrant cell proliferation is a hallmark of cancer, including breast cancer. Here, we show that USP27X is required for cell proliferation and tumorigenesis in breast cancer. We identify a PIM2-USP27X regulato...

    Xue Han, Chune Ren, Chao Lu, Aifang Jiang, **aoyun Wang, Lan Liu, Zhenhai Yu in Oncogene (2024)

  2. Article

    Open Access

    Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy

    The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...

    Cheng-Fei Du, Zhen-Yu Gao, Zhu-Ding Xu, Zheng-Kang Fang, Zi-Chen Yu in BMC Cancer (2024)

  3. No Access

    Article

    Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation

    Lung adenocarcinoma (LUAD) is one of the most prevalent types of cancer. Ubiquitination is crucial in modulating cell proliferation and aerobic glycolysis in cancer. The frequency of TP53 mutations in LUAD is app...

    Leifeng Chen, Lin Zhang, Haihua He, Fei Shao, Zhentao Yu, Yibo Gao, Jie He in Oncogene (2024)

  4. Article

    Open Access

    Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

    Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao in Signal Transduction and Targeted Therapy (2024)

  5. No Access

    Article

    Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC

    Metastasis causes most cancer-related deaths, and the role and mechanism of periostin (POSTN) in the metastasis of hepatocellular carcinoma (HCC) remain undiscovered. In this study, DEN and HTVi HCC models wer...

    Tuo Deng, Jungang Zhao, Yifan Tong, Ziyan Chen, Bangjie He, Jiacheng Li in Oncogene (2024)

  6. Article

    Open Access

    Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma

    Multiple myeloma (MM) remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell (CAR-T) therapy. Current targets of CAR-T cells used in MM immunotherapy have limitat...

    Zhengyu Yu, Hexian Li, Qizhong Lu in Signal Transduction and Targeted Therapy (2024)

  7. Article

    Open Access

    Correction: miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

    Shukai Yuan, Peitao Zhang, Liqi Wen, Shikai Jia, Yufan Wu, Zhenlei Zhang in Oncogene (2024)

  8. Article

    Open Access

    Comparison of different internal fixation models in ankle arthrodesis using 3D finite-element analysis

    The purpose of this study is to use three-dimensional finite-element analysis to better understand the biomechanical features of various internal fixators for ankle arthrodesis.

    Bo Feng, Qing-bo Gao, Guang-ming Dai, Ke-cheng Niu in European Journal of Medical Research (2023)

  9. Article

    Open Access

    Exploration and validation of a novel signature of seven necroptosis-related genes to improve the clinical outcome of hepatocellular carcinoma

    Necroptosis has been reported to be involved in cancer progression and associated with cancer prognosis. However, the prognostic values of necroptosis-related genes (NRGs) in hepatocellular carcinoma (HCC) rem...

    Qiqi Tao, Zhichao Lang, Yifei Li, Yuxiang Gao, Lifan Lin, Zheng** Yu in BMC Cancer (2023)

  10. Article

    Open Access

    Comparison of clinical characteristics between adult-onset and juvenile-onset non-radiographic axial spondyloarthritis in Chinese patients: results from the COCAS cohort

    Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease predominantly affecting the axial skeleton. We aimed to describe the clinical characteristics of patients with non-radiographic axSpA...

    Shu-**n Huang, Hao-Guang Li, Hong-** Liang in European Journal of Medical Research (2023)

  11. Article

    Open Access

    CACA guidelines for holistic integrative management of esophageal carcinoma

    Esophageal carcinoma (EC) is a common malignant tumor of the upper digestive tract worldwide. An analysis of the latest data from cancer centers in China showed that the incidence of EC and the number of death...

    Lei Gong, Ming Bai, Liang Dai, Xufeng Guo, Xuefeng Leng in Holistic Integrative Oncology (2023)

  12. Article

    Open Access

    Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

    Zhenlong Yu, Jian Gao, **aolei Zhang in Signal Transduction and Targeted Therapy (2023)

  13. Article

    Open Access

    SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

    Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the...

    Pan Pan, Weiwei Ge, Zhiwei Lei, Wei luo in Signal Transduction and Targeted Therapy (2023)

  14. Article

    Open Access

    High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis

    PTPRF interacting protein alpha 1 (PPFIA1) is reportedly related to the occurrence and progression of several kinds of malignancies. However, its role in esophageal squamous cell carcinoma (ESCC) is unclear. T...

    Yongyin Gao, Lizhao Guan, Ran Jia, Wanyi **ao, Youming Han, Yue Li, Peng Tang in BMC Cancer (2023)

  15. Article

    Open Access

    Machine learning integrations develop an antigen-presenting-cells and T-Cells-Infiltration derived LncRNA signature for improving clinical outcomes in hepatocellular carcinoma

    As a highly heterogeneous cancer, the prognostic stratification and personalized management of hepatocellular carcinoma (HCC) are still challenging. Recently, Antigen-presenting-cells (APCs) and T-cells-infilt...

    **aodong Wang, Ji Chen, Lifan Lin, Yifei Li, Qiqi Tao, Zhichao Lang in BMC Cancer (2023)

  16. Article

    Open Access

    Analysis of the differential expression and prognostic relationship of DEGs in AML based on TCGA database

    Acute myeloid leukemia (AML) is a common and lethal hematological malignant hyperplastic disease originating from hematopoietic stem cells. The purpose of this study is to obtain the key differentially express...

    Yue Gao, Yinnong Jia, Zhengmin Yu, **nyu Ji in European Journal of Medical Research (2023)

  17. Article

    Open Access

    A comprehensive study based on exosome-related immunosuppression genes and tumor microenvironment in hepatocellular carcinoma

    Exosomes play an important role in the tumor microenvironment (TME) and the mechanisms of tumor immune escape in hepatocellular carcinoma (HCC). It is known that immunosuppressive genes, involved in the proces...

    Zhan Yang, **nmiao Li, Chaoran Pan, Yifei Li, Lifan Lin, Yan ** in BMC Cancer (2022)

  18. Article

    Open Access

    Comparison of clinicopathological features and prognostic significance between synchronous multiple primary and solitary esophageal squamous cell carcinomas

    Synchronous multiple primary esophageal squamous cell carcinoma (S-MPESCC) refers to more than one primary esophageal carcinoma detected in a solitary patient at the time of initial presentation. The purpose o...

    Yueyang Yang, Peng Tang, Mingquan Ma, Hongdian Zhang, Haitong Wang, Kai Zhu in BMC Cancer (2022)

  19. Article

    Open Access

    The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells

    Although the abnormal expression of miRNAs in cancer cells is a widely accepted phenomenon, the molecular mechanisms underlying miR-3648 progression and metastasis in gastric cancer (GC) remain unclear. miR-36...

    Weimei Tang, Miaomiao Pei, Jiaying Li, Nanzhu Xu, Wushuang **ao, Zhen Yu in Oncogene (2022)

  20. Article

    Open Access

    Correction to: NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

    Tengfei Fan, **aoning Wang, Sheng Zhang in Signal Transduction and Targeted Therapy (2022)

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