161 Result(s)
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Article
Stress protein synthesis by crayfish CNS tissue in vitro
Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypo...
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Article
Stress protein synthesis and accumulation after traumatic injury of crayfish CNS
By several days after a crush injury of crayfish CNS, the wound site heals. Changes in protein synthesis and accumulation occur at the lesion site and nearby. During the first few hours, synthesis of 35, 70, 9...
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Article
New carotenoids from the thermophilic green sulfur bacterium Chlorobium tepidum: 1′,2′-dihydro-γ-carotene, 1′,2′-dihydrochlorobactene, and OH-chlorobactene glucoside ester, and the carotenoid composition of different strains
The complete carotenoid composition of the thermophilic green sulfur bacterium Chlorobium tepidum strain TNO was determined by spectroscopic methods. Major carotenoids were four kinds of carotenes: γ-carotene, c...
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A new method for protein domain recognition
A fuzzy cluster method is presented to recognize protein domains. This algorithm can identify domains globally. A protein structure set was used to test the algorithm. Among 219 proteins, 66.7% yielded result...
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Changes of ATP and ADP in Cultured Astrocytes Under and After in Vitro Ischemia
A very large body of evidence from in vivo studies has been accumulated on a link between the change of energy and cell survival/apoptosis. Using an in vitro ischemia model, we have previously shown that ische...
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Article
PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway
Peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1 alpha (PGC-1α) coactivates multiple transcription factors and regulates several metabolic processes. The current study investigated the ro...
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Article
Rig-I−/− mice develop colitis associated with downregulation of Gαi2
RIG-I (retinoid acid-inducible gene-I), a putative RNA helicase with a cytoplasmic caspase-recruitment domain (CARD), was identified as a pattern-recognition receptor (PRR) that mediates antiviral immunity by ...
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Article
Expression differentiation of CYC-like floral symmetry genes correlated with their protein sequence divergence in Chirita heterotricha (Gesneriaceae)
CYCLOIDIEA (CYC) and its homologues have been studied intensively in the model organism Antirrhinum majus and related species regarding their function in controlling floral dorsoventral (adaxial–abaxial) asymmetr...
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Article
Comparative Proteomics Analysis of Cerebrospinal Fluid of Patients with Guillain–Barré Syndrome
To better understand the pathophysiologic mechanisms underlying Guillain–Barré syndrome (GBS), Comparative proteomic analysis of cerebrospinal fluid (CSF) between patients with GBS (the experiment group) and c...
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Article
Microbial diversity in lake sediments detected by PCR-DGGE
In this study, PCR-denaturing gradient gel electrophoresis (DGGE) was applied to analyze the microbial communities in lake sediments from Lake Xuanwu, Lake Mochou in Nan**g and Lake Taihu in Wuxi. Sediment sa...
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Vesicular stomatitis virus matrix protein gene enhances the antitumor effects of radiation via induction of apoptosis
Vesicular stomatitis virus (VSV) matrix (M) protein can directly induce apoptosis by inhibiting host gene expression when it is expressed in the absence of other viral components. Previously, we found that the...
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Article
The Expression Pattern of Heterogeneous Nuclear Ribonucleoprotein R in Rat Retina
The heterogeneous nuclear ribonucleoproteins (hnRNPs) play important roles in DNA repairing, cell signaling, telomere biogenesis, and in regulating gene expression at both transcriptional and translational lev...
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Article
Zinc Deficiency Reduces Neurogenesis Accompanied by Neuronal Apoptosis Through Caspase-Dependent and -Independent Signaling Pathways
Dietary zinc deficiency may affect zinc homeostasis in the brain and lead to reductions of neurogenesis and neuronal survival. However, the mechanisms responsible for the effects of zinc deficiency on hippocam...
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Article
Nitrogen fixation of epiphytic plants enwrap** trees in Ailao Mountain cloud forests, Yunnan, China
Epiphytic plants play an important role in the nutrient cycle of forest ecosystems. There had been fewer studies in subtropical regions than in other climate zones. Prior research showed that the canopy epiphy...
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Exposure to Pyrithiamine Increases β-Amyloid Accumulation, Tau Hyperphosphorylation, and Glycogen Synthase Kinase-3 Activity in the Brain
Decreased thiamine-dependent enzyme activity and/or thiamine deficiency (TD) have been linked to Alzheimer’s disease (AD). In this study, we administered pyrithiamine, an anti-thiamine compound, to both APP/PS...
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Excess Thyroid Hormone Inhibits Embryonic Neural Stem/Progenitor Cells Proliferation and Maintenance through STAT3 Signalling Pathway
Hyperthyroidism is prevalent during pregnancy, but little is known about the effects of excess thyroid hormone on the development of embryonic neural stem/progenitor cells (NSCs), and the mechanisms underlying...
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The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation
The MRE11/RAD50/NBS1 complex is the primary sensor rapidly recruited to DNA double-strand breaks (DSBs). MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif. In this ...
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Article
Artificial Cold Wave-Induced Cerebral Infarction in Rats with Carotid Atherosclerosis
To investigate the effects of cold on blood pressure, serum endothelin-1 content, serum nitric oxide content, and morbidity of cerebral infarction, as well as assess the therapeutic effect of nimodipine. A tot...
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Article
Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein
Accumulation of α-synuclein (α-Syn) is a common pathology for both familiar and sporadic Parkinson’s disease (PD), enhancing its clearance might be a promising strategy for treating PD. To assess the potential...
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Article
Cancer Microenvironment and Cancer Vaccine
The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal an...