116 Result(s)

Article

Global analysis of microRNA target gene expression reveals the potential roles of microRNAs in maintaining tissue identity

MicroRNAs are non-coding small RNAs of ~22 nucleotides that regulate the gene expression by base-paring with target mRNAs, leading to mRNA cleavage or translational repression. It is currently estimated that m...

Zhenbao Yu, Zhaofeng Jian, Shi-Hsiang Shen, Enrico Purisima, Edwin Wang in Genome Biology (2005)

Article

PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway

Peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1 alpha (PGC-1α) coactivates multiple transcription factors and regulates several metabolic processes. The current study investigated the ro...

Yan Zhang, Yi Ba, Chang Liu, Guoxun Sun, Li Ding, Songyuan Gao, Jihui Hao… in Cell Research (2007)

Article

Rig-I^−/− mice develop colitis associated with downregulation of Gαi2

RIG-I (retinoid acid-inducible gene-I), a putative RNA helicase with a cytoplasmic caspase-recruitment domain (CARD), was identified as a pattern-recognition receptor (PRR) that mediates antiviral immunity by ...

Yi Wang, Hong-**n Zhang, Yue-** Sun, Zi-**ng Liu, Xue-Song Liu… in Cell Research (2007)

Article

Docosahexaenoic acid has influence on action potentials and transient outward potassium currents of ventricular myocytes

There are many reports about the anti-arrhythmic effects of ω-3 polyunsaturated fatty acids, however, the mechanisms are still not completely delineated. The purpose of this study was to investigate the charac...

Ru-xing Wang, **ao-rong Li, Tao Guo, Li-** Sun… in Lipids in Health and Disease (2010)

Article

Discrimination of n-3 Rich Oils by Gas Chromatography

Exploring the capabilities of instrumental techniques for discriminating n-3 rich oils derived from animals is a very important though much neglected area that was emphasized more than 100 years ago. In this s...

Pedro Araujo, Yingxu Zeng, Zhen-Yu Du, Thu-Thao Nguyen, Livar Frøyland… in Lipids (2010)

Article

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

The MRE11/RAD50/NBS1 complex is the primary sensor rapidly recruited to DNA double-strand breaks (DSBs). MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif. In this ...

Zhenbao Yu, Gillian Vogel, Yan Coulombe, Danielle Dubeau… in Cell Research (2012)

Article

Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model

Cell therapy is a potential therapeutic approach for neurodegenerative disorders, such as Alzheimer disease (AD). Neuronal differentiation of stem cells before transplantation is a promising procedure for cell...

Hui Yang, Zhao Hong **e, Li Fei Wei, Hong Na Yang… in Stem Cell Research & Therapy (2013)

Article

The evolution of floral deception in Epipactis veratrifolia (Orchidaceae): from indirect defense to pollination

It is estimated that floral deception has evolved in at least 7500 species of angiosperms, of which two thirds are orchids. Epipactis veratrifolia (Orchidaceae) is a model system of aphid mimicry as aphidophagous...

**ao-Hua **, Zong-**n Ren, Song-Zhi Xu, Hong Wang, De-Zhu Li… in BMC Plant Biology (2014)

Article

Solubilization and purification of recombinant modified C-reactive protein from inclusion bodies using reversible anhydride modification

The precise function of C-reactive protein (CRP) as a regulator of inflammation in health and disease continues to evolve. The true understanding of its role in host defense responses has been hampered by nume...

Lawrence A. Potempa, Zhen-Yu Yao, Shang-Rong Ji, János G. Filep… in Biophysics Reports (2015)

Article

Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population

In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic ...

Wen-Yi Yang, Thibault Petit, Lutgarde Thijs, Zhen-Yu Zhang, Lotte Jacobs… in BMC Genetics (2015)

Article

Autophagy promotes apoptosis of mesenchymal stem cells under inflammatory microenvironment

Mesenchymal stem cells (MSCs) have been widely applied to treat various inflammatory diseases. Inflammatory cytokines can induce both apoptosis and autophagy in MSCs. However, whether autophagy plays a pro- or...

Shipeng Dang, Zhi-ming Yu, Chang-ying Zhang, Jie Zheng… in Stem Cell Research & Therapy (2015)

Article

A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs

Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter ...

Lei Chen, Weiwei Guo, Lili Ren, Mingyao Yang, Yaofeng Zhao, Zongyi Guo… in BMC Biology (2016)

Article

CloneCNA: detecting subclonal somatic copy number alterations in heterogeneous tumor samples from whole-exome sequencing data

Copy number alteration is a main genetic structural variation that plays an important role in tumor initialization and progression. Accurate detection of copy number alterations is necessary for discovering ca...

Zhenhua Yu, Ao Li, Minghui Wang in BMC Bioinformatics (2016)

Article

Kinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-κB signaling in macrophages and protecting endothelial cells

Gouty arthritis is a rheumatic disease that is characterized by the deposition of monosodium urate (MSU) in synovial joints cause by the increased serum hyperuricemia. This study used a three-dimensional (3D) ...

Qiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-he, Zheng Yu-hua… in Cell Death & Disease (2016)

Article

1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes

Impaired apoptosis of fibroblast-like synoviocytes (FLSs) causes synovial hyperplasia, facilitating destruction of cartilage and bone in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α, a dominant inflam...

**n Gu, Bingjie Gu, **anhui Lv, Zhenzhen Yu, Rong Wang, … in Cell Death & Disease (2016)

Article

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

Intracellular accumulation of the hyperphosphorylated tau is a pathological hallmark in the brain of Alzheimer disease. Activation of extrasynaptic NMDA receptors (E-NMDARs) induces excitatory toxicity that is...

Xu-Ying Sun, Qing-Zhang Tuo, Zhen-Yu Liuyang, Ao-Ji **e… in Cell Death & Disease (2016)

Article

Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We sought to determine whether MSCs could ...

Dan Jiang, Fei Gao, Yuelin Zhang, David Sai Hung Wong, Qing Li… in Cell Death & Disease (2016)

Article

A continuous analog of run length distributions reflecting accumulated fractionation events

We propose a new, continuous model of the fractionation process (duplicate gene deletion after polyploidization) on the real line. The aim is to infer how much DNA is deleted at a time, based on segment length...

Zhe Yu, David Sankoff in BMC Bioinformatics (2016)

Article

Erratum to: Lysinibacillus endophyticus sp. nov., an indole-3-acetic acid producing endophytic bacterium isolated from corn root (Zea mays cv. **nken-5)

Jiang Yu, Xuejiao Guan, Chongxi Liu, Wensheng **ang, Zhenhua Yu… in Antonie van Leeuwenhoek (2017)

Article

Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers worldwide. CD147 (EMMPRIN or basigin) is a leading gene relating to hepatocarcinogenesis and metastasis, and is detected in transm...

Bo Wu, Jian Cui, **ang-Min Yang, Zhen-Yu Liu, Fei Song, Ling Li… in Cell Death & Disease (2017)