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Open AccessA Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain
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Open AccessPhosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been iden...
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Open AccessCryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies
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Structural mechanism for specific binding of chemical compounds to amyloid fibrils
Amyloid fibril is an important pharmaceutical target for diagnostic and therapeutic treatment of neurodegenerative diseases. However, rational design of chemical compounds that interact with amyloid fibrils is...
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Influence of Free Ammonia Concentration on Heterotrophic Nitrification—Aerobic Denitrification Process by Strain Pseudomonas otitidis YM-01
Pseudomonas otitidis YM-01, which was isolated from swine wastewater, showed efficient simultaneous nitrification and denitrification ability by effectively using a single nitrogen source and a mixed nitrogen so...
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Open AccessHeparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology
α-Synuclein (α-syn), as a primary pathogenic protein in Parkinson’s disease (PD) and other synucleinopathies, exhibits a high potential to form polymorphic fibrils. Chemical ligands have been found to involve ...
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Open AccessGeneric amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders
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Open AccessParkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causati...
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Open AccessDinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
Efficient and site-specific chemical modification of proteins under physiological conditions remains a challenge. Here we report that 1,4-dinitroimidazoles are highly efficient bifunctional bioconjugation reag...
