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Article
Association of expression of GADD family genes and apoptosis in human kidney proximal tubular (HK-2) cells exposed to nephrotoxic drugs
Nephrotoxicity is often referred to as a side effect of most drugs, but methods for effectively detecting nephrotoxicants still require development.
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Article
Rare minisatellite alleles of MUC2-MS8 influence susceptibility to rectal carcinoma
Previously, we identified eight novel minisatellites in the MUC2, of which allelic variants in MUC2-MS6 were examined to influence susceptibility to gastric cancer. However, studies on the susceptibility to gastr...
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Article
Open AccessModulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
Impaired hippocampal synaptic plasticity contributes to cognitive impairment in Huntington’s disease (HD). However, the molecular basis of such synaptic plasticity defects is not fully understood. Combining li...
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Article
Open AccessDNA Methylome Analysis of Saturated Aliphatic Aldehydes in Pulmonary Toxicity
Recent studies have investigated the epigenetic effects of environmental exposure to chemicals on human health. The associations of DNA methylation, environmental exposure and human diseases have been widely d...
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Article
A study of cytotoxicity and genotoxicity of particulate matter (PM2.5) in human lung epithelial cells (A549)
Exposure to airborne particulate matter (PM2.5), a PM with an aerodynamic diameter of less than 2.5 μm, is known to be associated with a variety of adverse health effects, particularly related to the respiratory ...
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Article
Expression of exosomal and cellular microRNAs: as biomarkers for toluene, ethylbenzene, xylene (TEX) exposure
Exosomes, small vesicles released by many cells, are associated with various biological processes and they can potentially be used for prognosis and therapy and as biomarkers of health. Thus, they are gaining ...
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Article
Analysis of gene expression changes in relation to hepatotoxicity induced by perfluorinated chemicals in a human hepatoma cell line
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) represent a rising class of persistent organic pollutants termed perfluorinated chemicals (PFCs). In this study, hepatotoxic effects of PFCs w...
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Article
Hexanal-induced changes in miRNA-mRNA interactions in A549 human alveolar epithelial cells
Although hexanal is considered to be a major air pollutant the correlation between hexanal and health risk is largely unknown. Identifying aldehyde toxicity in eukaryotic cells will be useful for preventing an...
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Article
Gene expression profiling of human alveolar epithelial cells (A549 cells) exposed to atmospheric particulate matter 2.5 (PM2.5) collected from Seoul, Korea
Many epidemiological and in vitro studies have shown that particulate matter 2.5 (PM2.5) is associated with adverse health effects in humans, especially respiratory morbidity and mortality1–3. While the mechanism...
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Article
Analysis of dose-response to hexanal-induced gene expression in A549 human alveolar cells
The problems of analyzing dose effects on gene expression are gaining attention in toxicological research. Determining how gene expression profiles change with toxicant dose will improve the utility of arrays ...
