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  1. Article

    Open Access

    Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

    Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

    Zhenglong Guo, Yongchang Zhu, Hai **ao, Ranran Dai, Wenke Yang… in Biological Research (2023)

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  2. Article

    Open Access

    Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers

    CD4+ and CD8+ double-positive (DP) thymocytes play a crucial role in T cell development in the thymus. DP cells rearrange the T cell receptor gene Tcra to generate T cell receptors with TCRβ. DP cells differentia...

    Delong Feng, Yanhong Chen, Ranran Dai, Shasha Bian, Wei Xue… in Nature Communications (2022)

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  3. Article

    Open Access

    Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

    Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transactivator of viral and cellular gene expression, which plays a critical role in the Epstein-Barr virus-associated diseases. It was reported that EBNA2 reg...

    Yiting Yang, **dong Ye, Ranran Dai, Zhaoqiang Li, Yan Zhang… in Communications Biology (2021)

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  4. Article

    Open Access

    Downregulation by CNNM2 of ATP5MD expression in the 10q24.32 schizophrenia-associated locus involved in impaired ATP production and neurodevelopment

    Genome-wide association studies (GWAS) have accelerated the discovery of numerous genetic variants associated with schizophrenia. However, most risk variants show a small effect size (odds ratio (OR) <1.2), su...

    Zhongju Wang, Yongchang Zhu, Linyan Ye, Qiyang Li, Bo Guo, Hao Zhao… in npj Schizophrenia (2021)

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