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Article
Open AccessTannic acid modified keratin/sodium alginate/carboxymethyl chitosan biocomposite hydrogels with good mechanical properties and swelling behavior
Natural polymer-based hydrogels have demonstrated great potential as wound-healing dressings. They help to maintain a moist wound environment as well as promote faster healing. In this work, a multifunctional ...
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Article
Open AccessIntegrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases
The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentratio...
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Article
Supernatural Beliefs-Based Intervention to Improve Type-2 Diabetes Self-Management: A Pilot Randomized Controlled Trial from China
China has over 100 million people living with type 2 diabetes mellitus (T2DM). Interventions framed around pre-existing personal beliefs in the supernatural may improve T2DM self-management, but such intervent...
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Article
Global receptive field graph attention network for unsupervised domain adaptation fault diagnosis in variable operating conditions
While deep learning has advanced significantly in machinery diagnosis, models trained on source domain data struggle with real-world applications due to varying operating conditions in the target domain. To ad...
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Article
In situ reconstruction induced oxygen-deficient multiphase Cu based species hybridized with Ni single atoms as tandem platform for CO2 electroreduction
Tandem catalysis, capable of decoupling individual steps, provides a feasible way to build a high-efficiency CO2 electroconversion system for multicarbons (C2+). The construction of electrocatalytic materials is ...
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Article
Open AccessMetabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers associated with treatment response of neoadjuvant therapy with TCbHP regimen in HER2 + breast cancer
This study aimed to explore potential indicators associated with the neoadjuvant efficacy of TCbHP regimen (taxane, carboplatin, trastuzumab, and pertuzumab) in HER2 + breast cancer (BrCa) patients.
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Article
Construction and Validation of a Clinical Prediction Model for Predicting Tubal Pregnancy Rupture Based on Nomogram
To explore the risk factors for tubal rupture in tubal pregnancy, construct and validate a prediction model for tubal rupture.
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Article
Open AccessA qualitative study on patients’ and health care professionals’ perspectives regarding care delivered during CIED operation
Cardiac implantable electronic devices (CIEDs) has proven to be an invaluable tool in the practice of cardiology. Patients who have undergone CIED surgery with local anesthesia may result in fear, insecurity a...
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Article
An Ultra-low Detection Limit Fe3+ Optical Fiber Fluorescent Sensor Based on a Anti-B18H22 Derivative with Aggregation-induced Emission Enhancement
A fluorescent Fe3+ probe ((C10H7NO2)2B18H20, M1) by introducing two isoquinoline-1-carboxylic acid group into the 6,9-position of anti-B18H22 was designed and synthesized. The structure of M1 was investigated by
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Article
Open AccessMetagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of...
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Article
Advances in DNA methylation and demethylation in medicinal plants: a review
DNA methylation and demethylation are widely acknowledged epigenetic phenomena which can cause heritable and phenotypic changes in functional genes without changing the DNA sequence. They can thus affect pheno...
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Article
Online machine learning for stream wastewater influent flow rate prediction under unprecedented emergencies
Accurate influent flow rate prediction is important for operators and managers at wastewater treatment plants (WWTPs), as it is closely related to wastewater characteristics such as biochemical oxygen demand (...
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Article
Quantifying into wh-dependencies: multiple-wh questions and questions with a quantifier
Questions with a quantificational subject have readings that seemingly involve quantification into questions (called ‘QiQ’ for short). In particular, in single-wh questions with a universal quantifier, QiQ-readin...
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Article
Open AccessMulti-omics analysis reveals gut microbiota-ovary axis contributed to the follicular development difference between Meishan and Landrace × Yorkshire sows
The mechanism by which Meishan (MS) sows are superior to white crossbred sows in ovarian follicle development remains unclear. Given gut microbiota could regulate female ovarian function and reproductive capac...
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Article
Acceptor-acceptor type polymers based on cyano-substituted benzochalcogenadiazole and diketopyrrolopyrrole for high-efficiency n-type organic thermoelectrics
The development of n-type organic thermoelectrics (OTEs) falls significantly behind that of their p-type counterparts. Herein, two acceptor-acceptor (A-A) polymers, PDCNBT-DPP and PDCNBSe-DPP, were generated b...
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Article
Co-pyrolysis of algae with other carbon-based materials: a review on synergistic products and molecular reaction pathway
As a kind of pyrolysis feedstock, algae has shown great potential in generating valuable products such as pyrolytic oil, gas and semi-coke. Thermal transformation of algae and other carbon-based materials via ...
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Article
Open AccessAssociation between age at menarche and bone mineral density in postmenopausal women
Age at menarche (AAM) directly affects female estrogen levels, which play a vital role in bone metabolism. The exact relationship between bone mineral density (BMD) and AAM remains controversial. Thus, this st...
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Article
Decay stages and meteorological factors affect microbial community during leaf litter in situ decomposition
• Decay stages and meteorological factors affect leaf litter’s microbial community.
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Article
Comprehensive evaluation of spent mushroom substrate-chicken manure co-composting by garden waste improvement: physicochemical properties, humification process, and the spectral characteristics of dissolved organic matter
The performance of garden waste on spent mushroom substrate (SMS) and chicken manure (CM) co-composting efficiency and humification is unclear. Therefore, this study investigated the impact of garden waste add...
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Article
Preparation of novel HKUST-1-glucose oxidase composites and their application in biosensing
Copper-based metal–organic frameworks (MOF) and multi-walled carbon nanotubes (HKUST-1-MWCNTs) composite were synthesized by one-step hydrothermal method, and PDA-enzyme-HKUST-1-MWCNTs composite was prepared b...