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Article
A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys
Retrograde adeno-associated viruses (AAVs) are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural networks. However, ...
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Article
Open AccessA novel frequency-dependent lattice Boltzmann model with a single force term for electromagnetic wave propagation in dispersive media
Electromagnetic wave simulation is of pivotal importance in the design and implementation of photonic nano-structures. In this study, we developed a lattice Boltzmann model with a single extended force term (L...
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Article
Open AccessA high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging
cAMP is a key second messenger that regulates diverse cellular functions including neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact organisms are largely unknown due to l...
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Article
Targeting thalamic circuits rescues motor and mood deficits in PD mice
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with Parkinson’s disease (PD), patients also experience motor learning impairments and non-motor symptoms such as depression1....
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Article
Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases
This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming a...
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Article
Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review
MCC950 has been proposed as a specific small molecule inhibitor that can selectively block NLRP3 inflammasome activation. However, the exact mechanism of its action is still ambiguous. Accumulating investigati...
