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Open AccessAssociation between atherosclerosis and height loss among older individuals
Atherosclerosis and height loss are each reportedly associated with cardiovascular disease. However, no studies have found an association between atherosclerosis and height loss. A retrospective study of 2435 ...
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Article
Open AccessAssociation between anti-thyroid peroxidase antibody and thyroid stimulating hormone: a cross-sectional study
To maintain normal level of thyroid hormone, especially for free thyroxine (FT4), individuals with latent thyroid gland damage might have required higher thyroid stimulating hormone (TSH) than those without la...
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Article
Open AccessAssociation between circulating CD34-positive cell count and height loss among older men
Height loss starting in middle age is reportedly significantly associated with death due to cardiovascular disease. Impaired blood flow is the main pathology in cardiovascular disease. Hematopoietic stem cells...
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Article
Open AccessVascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension
Angiogenesis inhibition therapy causes hypertension by increasing peripheral vascular resistance. Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. Since vascular endothelia...
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Article
Open AccessAssociation between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study
Our recent studies indicate that thyroid cysts have clinical implications. Thyroid cysts could have a positive effect on the supply of thyroid hormones. Both hyperthyroidism and hypothyroidism cause hypertensi...
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Article
Open AccessThe VH framework region 1 as a target of efficient mutagenesis for generating a variety of affinity-matured scFv mutants
In vitro affinity-maturation potentially generates antibody fragments with enhanced antigen-binding affinities that allow for develo** more sensitive diagnostic systems and more effective therapeutic agents....
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Open AccessAssociation between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates...
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Article
Open AccessPotential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population
Minor allele frequency (MAF) of rs3782886 (BRAP) and rs671 (ALDH2) are reported to be inversely associated with blood pressure. Another study revealed that hematopoietic activity which is evaluated by reticulo...
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Open AccessCirculating CD34+ cells and active arterial wall thickening among elderly men: A prospective study
Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (th...