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  1. Article

    Open Access

    Association between atherosclerosis and height loss among older individuals

    Atherosclerosis and height loss are each reportedly associated with cardiovascular disease. However, no studies have found an association between atherosclerosis and height loss. A retrospective study of 2435 ...

    Yuji Shimizu, Kazuhiko Arima, Hirotomo Yamanashi, Shin-Ya Kawashiri in Scientific Reports (2024)

  2. Article

    Open Access

    Association between anti-thyroid peroxidase antibody and thyroid stimulating hormone: a cross-sectional study

    To maintain normal level of thyroid hormone, especially for free thyroxine (FT4), individuals with latent thyroid gland damage might have required higher thyroid stimulating hormone (TSH) than those without la...

    Yuji Shimizu, Mutsumi Matsuyama, Yuko Noguchi, Midori Takada in Scientific Reports (2023)

  3. Article

    Open Access

    Association between circulating CD34-positive cell count and height loss among older men

    Height loss starting in middle age is reportedly significantly associated with death due to cardiovascular disease. Impaired blood flow is the main pathology in cardiovascular disease. Hematopoietic stem cells...

    Yuji Shimizu, Shin-Ya Kawashiri, Kenichi Nobusue, Fumiaki Nonaka in Scientific Reports (2022)

  4. Article

    Open Access

    Vascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension

    Angiogenesis inhibition therapy causes hypertension by increasing peripheral vascular resistance. Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. Since vascular endothelia...

    Yuji Shimizu, Kazuhiko Arima, Yuko Noguchi, Hirotomo Yamanashi in Scientific Reports (2022)

  5. Article

    Open Access

    Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study

    Our recent studies indicate that thyroid cysts have clinical implications. Thyroid cysts could have a positive effect on the supply of thyroid hormones. Both hyperthyroidism and hypothyroidism cause hypertensi...

    Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata in Scientific Reports (2021)

  6. Article

    Open Access

    The VH framework region 1 as a target of efficient mutagenesis for generating a variety of affinity-matured scFv mutants

    In vitro affinity-maturation potentially generates antibody fragments with enhanced antigen-binding affinities that allow for develo** more sensitive diagnostic systems and more effective therapeutic agents....

    Yuki Kiguchi, Hiroyuki Oyama, Izumi Morita, Yasuhiro Nagata in Scientific Reports (2021)

  7. Article

    Open Access

    Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study

    Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates...

    Yuji Shimizu, Hirotomo Yamanashi, Shoichi Fukui, Shin-Ya Kawashiri in Scientific Reports (2021)

  8. Article

    Open Access

    Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population

    Minor allele frequency (MAF) of rs3782886 (BRAP) and rs671 (ALDH2) are reported to be inversely associated with blood pressure. Another study revealed that hematopoietic activity which is evaluated by reticulo...

    Yuji Shimizu, Kazuhiko Arima, Yuko Noguchi, Shin-Ya Kawashiri in Scientific Reports (2020)

  9. Article

    Open Access

    Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study

    Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (th...

    Yuji Shimizu, Shin-Ya Kawashiri, Kairi Kiyoura, Jun Koyamatsu in Scientific Reports (2020)