3 Result(s)
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Article
Open AccessCRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits
High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. We aim to create APOC3-knockout (KO) rabbits and explore the effects of APOC3 dele...
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Article
Open AccessSeveral circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases
In recent years, an increasing number of studies have proved that circulating miRNAs could be used for the early diagnosis of cardiovascular diseases and even play vital roles in the evaluation of therapeutic ...
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Article
Open AccessGeneration of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system
To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.
