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Article
Open AccessAutophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis
Macrophages (Mφ) autophagy is a pivotal contributor to inflammation-related diseases. However, the mechanistic details of its direct role in acute kidney injury (AKI) were unclear. Here, we show that Mφ promot...
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Article
Adaptive coupling consensus of multi-agent systems with integral-based event-triggered mechanism
To solve the consensus of linear leaderless multi-agent systems, an adaptive coupling consensus integral-based event-triggered controller is discussed in this paper. Firstly, the dynamic equations of leaderles...
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Article
Highly efficient preferential adsorption of Pb(II) and Cd(II) from aqueous solution using sodium lignosulfonate modified illite
In this study, sodium lignosulfonate modified illite (LS-ILT), an environmentally friendly adsorbent, was prepared by hydrothermal modification. An extensive study of Pb(II) and Cd(II) adsorption behavior and ...
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Article
Open AccessMLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes
Cardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated in diabetic hearts. Deletion of RIPK3 was reported to attenuate myoca...
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Article
Modified Model Free Adaptive Control for a Class of Nonlinear Systems with Multi-threshold Quantized Observations
This paper addresses a pattern-moving-based modified model free adaptive control (PMFAC) scheme and illustrates the convergence of its tracking error for a class of nonlinear systems with unknown model and mul...
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Article
Open AccessMacrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases
Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in response to different pathogens or stimuli, and they are extensively involved in the pathology of various diseases. Extracellu...
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Article
Open AccessCorrection to: Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
The original article possessed a minor typo in first author, **n Zeng’s name which has since been corrected.
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Article
Open AccessOleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
Pyroptosis is a novel programmed cell death. It is identified as caspase-1 dependent and characterized by plasma-membrane rupture and release of proinflammatory intracellular contents inculuding IL-1 beta and ...
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Article
Open AccessIntervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model
Diabetic nephropathy (DN) is one of the most severe chronic diabetic complications and the main cause of end-stage renal disease. Chronic inflammation plays a key role in the development of DN. However, few tr...
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Article
Oleic acid protects insulin-secreting INS-1E cells against palmitic acid-induced lipotoxicity along with an amelioration of ER stress
It is demonstrated that unsaturated fatty acids can counteract saturated fatty acids-induced lipotoxicity, but the molecular mechanisms are unclear. In this study, we investigated the protective effects of mon...
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Article
Anonymous three-factor authenticated key agreement for wireless sensor networks
Secure information exchange in wireless sensor networks (WSN) is a continuing issue since the resource-constrained sensors generally deployed over an unattended environment. To access the real-time data from t...
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Article
Open AccessPeripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys
Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown a potential t...
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Article
Open AccessProtein–Protein Affinity Determination by Quantitative FRET Quenching
The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions. Recently, we reported the theoretical basis and experimental...
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Article
Open AccessMesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy
Mitochondrial dysfunction and excessive mitochondrial reactive oxygen species (ROS) are fundamental contributors to endothelial injury in diabetic states. Mesenchymal stem cells (MSCs) have exhibited an extrao...
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Article
A Novel Smart Card Based User Authentication and Key Agreement Scheme for Heterogeneous Wireless Sensor Networks
Due to the open environment in which hierarchical wireless sensor networks (HWSNs) are typically deployed, it is important to authenticate transmitted data. In recent years, a number of user authentication sch...
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Article
An anonymous two-factor authenticated key agreement scheme for session initiation protocol using elliptic curve cryptography
The Session Initiation Protocol (SIP) is a signaling protocol widely applied in the world of multimedia communication. Numerous SIP authenticated key agreement schemes have been proposed with the purpose of en...
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Article
Open AccessMetformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release
Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce cardiovascular complicati...
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Article
Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression
Xenotransplantation is a potential solution to the organ donor shortage. Immunosuppression is required for successful application of xenotransplantation but may lead to infection and cancer. Thus, strategies f...
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Article
A secure and efficient mutual authentication scheme for session initiation protocol
The Session Initiation Protocol (SIP) as the core signaling protocol for multimedia services is receiving much attention. Authentication is becoming increasingly crucial issue when a user asks to use SIP servi...
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Article
WT1 Expression in Circulating RNA as a Minimal Residual Disease Marker for AML Patients After Stem-Cell Transplantation
Circulating RNA in plasma (CRNA) refers to soluble tumor-derived ribonucleic acids (RNA). The Wilms tumor 1 (WT1) gene appears to be a highly promising marker for minimal residual disease (MRD) detection in acute...
