14 Result(s)

Article

IKK1 aggravates ischemia–reperfusion kidney injury by promoting the differentiation of effector T cells

Ischemia–reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI), and experimental work has revealed detailed insight into the inflammatory response in the kidney. T cells and NFκB pat...

Ning Song, Yang Xu, Hans-Joachim Paust, Ulf Panzer… in Cellular and Molecular Life Sciences (2023)

Article

Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer

Immunotherapy has been widely utilized in multiple tumors, however, its efficacy in the treatment of triple-negative breast cancers (TNBC) is still being challenged. Meanwhile, functions and mechanisms of RNA ...

**rui Zhang, Ge Zhang, Wen**g Zhang, Lu Bai, Luning Wang… in Cell Death & Differentiation (2022)

Article

The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells

One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in the biosynthetic needs of unchecked proliferation, abrogating cell death programs, and immunologic esca...

Wenwen Gao, Mengqiu Huang, ** Chen, Jian** Chen, Zhiwei Zou… in Cell Death & Disease (2021)

Article

MiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex

Neonatal hypoxic–ischemic (HI) injury derived from asphyxia during perinatal period, is a serious complication of neonatal asphyxia and the main cause of neonatal acute death and chronic neurological injury. A...

Zi-Bin Zhang, Liu-Lin **ong, Lu-Lu Xue, Yan-** Deng, Ruo-Lan Du… in Cell Death & Disease (2021)

Article

The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism

Tempol (4-hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, TPL), a nitroxide compound, inhibits proliferation and increases the vulnerability of cancer cells to apoptosis induced by cytotoxic agents. However, the...

Shuangyan Ye, Pengfei Xu, Mengqiu Huang, ** Chen, Sisi Zeng… in Cell Death & Disease (2020)

Article

Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response

Growth factor receptor bound protein 2 (Grb2) is an adaptor protein critical for signal transduction and endocytosis, but its role in DNA damage response (DDR) remains unknown. Here, we report that either knoc...

Bolin Hou, Shanshan Xu, Yang Xu, Quan Gao, Caining Zhang, Ling Liu… in Cell Death & Disease (2019)

Article

Long non-coding RNA linc00665 promotes lung adenocarcinoma progression and functions as ceRNA to regulate AKR1B10-ERK signaling by sponging miR-98

Long non-coding RNAs (lncRNAs) are frequently dysregulated in multiple malignancies, demonstrating their potential oncogenic or tumor-suppressive roles in tumorigenesis. Herein, we reported the identification ...

Zhuangzhuang Cong, Yifei Diao, Yang Xu, **aokun Li, Zhisheng Jiang… in Cell Death & Disease (2019)

Article

Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals

In mammals, oocytes are arrested at the diplotene stage of meiosis I until the pre-ovulatory luteinizing hormone (LH) surge triggers meiotic resumption through the signals in follicular granulosa cells. In thi...

Wei Liu, Qiliang **n, **ao Wang, Sheng Wang, Huarong Wang… in Cell Death & Disease (2017)

Article

Regulation of p53 responses by post-translational modifications

Yang Xu in Cell Death & Differentiation (2003)