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490 Result(s)
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Article
Open AccessSETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
Transposable elements play a critical role in maintaining genome architecture during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of transposable elements, are known to harbor...
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Article
Open AccessActivation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η
This study aimed to explore the effects of peroxisome proliferator-activated receptor α (PPAR-α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its related mechanisms. ...
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Enhanced electrochemical performance of PEO/Li6.4Ga0.2La3Zr2O12 composite polymer electrolytes
All-solid-state lithium batteries (ASSLBs) are regarded as the most promising alternative to traditional liquid lithium-ion batteries due to their high-energy density and excellent safety. As an important part...
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Effects of hexamethylenetetramine as an electrolyte additive on elevated temperature performance of graphite/LiMn2O4 batteries
Spinel LiMn2O4-based lithium-ion batteries are widely applied in electric two-wheeler and low-speed vehicles due to their low cost and low toxicity. Nevertheless, the Mn deposition at the anode originated from Mn...
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Open AccessCCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosino...
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Article
Open AccesscircSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA
Lung cancer is the primary cause of cancer-related death worldwide, and its global incidence and mortality rates remain high. The differential expression of circular RNAs (circRNAs) can affect the development ...
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Open AccessTriglyceride Glucose Index for the Detection of Diabetic Kidney Disease and Diabetic Peripheral Neuropathy in Hospitalized Patients with Type 2 Diabetes
The triglyceride–glucose index (TyG) has been identified as a dependable and simple indicator marker of insulin resistance (IR). Research has demonstrated a correlation between macrovascular complications and ...
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Article
Fully printed IGZO memristor arrays with robust threshold switching characteristics for artificial nociceptors
The large-scale fabrication and patterning of artificial perceptual systems are vital for the development of bionic systems. Traditional patterning processes are often constrained by the use of mask versions, ...
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Article
Simulation of the in-flight background and performance of DRO/GTM
As a new member of the high energy astronomical transient monitoring network, Gamma-ray Transient Monitor (GTM) is an all-sky monitor onboard the Distant Retrograde Orbit (DRO) mission which has been launched ...
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Article
Correlation study of functional magnetic resonance index and clinicopathological features of rectal cancer
To investigate the correlation between DCE-MRI, R2*, IVIM, and clinicopathological features of rectal cancer.
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Article
The emerging role of the semaphorin family in cartilage and osteoarthritis
In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal pathway, thereby contributing to the pathological remodeling of the joint. Semaphorins (...
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Article
Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave: a single-center cohort study
Following the short-term outbreak of Coronavirus disease 2019 (COVID-19) in December 2022 in China, clinical data on kidney transplant recipients (KTRs) with COVID-19 are lacking.
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Article
Effect of Phase Separation Size on the Properties of Self-healing Elastomer
Regulation of phase structure has been recognized as one of the most effective ways to fabricate self-healing polymers with high mechanical strength. The mechanical properties of the resultant polymers are cer...
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Article
GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer
Receptor-interacting protein kinase 4 (RIPK4) is increasingly recognized as a pivotal player in ovarian cancer, promoting tumorigenesis and disease progression. Despite its significance, the posttranslational ...
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Article
Effects of an anti-WSSV transgenic cyanobacterial oral agent on the development, reproduction, and physiology of Daphnia magna
Trans-vp28 gene cyanobacteria have good efficacy as an oral agent against shrimp white spot syndrome virus (WSSV) infection in shrimp and have promising applications. However, little research on the environmental...
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Article
CAV1 Protein Encapsulated in Mouse BMSC-Derived Extracellular Vesicles Alleviates Myocardial Fibrosis Following Myocardial Infarction by Blocking the TGF-β1/SMAD2/c-JUN Axis
Extracellular vesicles (EVs) derived from mouse bone marrow mesenchymal stem cells (mBMSCs) convey the CAV1 protein, influencing the TGF-β1/SMAD2/c-JUN pathway and thus the molecular mechanisms underlying myoc...
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Article
Clipped seismic record recovery analysis based on the cubic spline interpolation algorithm
The clip** of near-field seismic waveforms caused by instrument limitations results in the waste of lots of waveforms and hinders the effective advancement of seismic research projects like source parameter ...
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Open AccessTherapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)
ARID1A, a component of the SWI/SNF chromatin-remodeling complex, is frequently mutated in various cancer types and has emerged as a potential therapeutic target. In this study, we observed that ARID1A-deficien...
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Article
Silicon PIN array-based charge measurement detector for HERD beam test
The high-energy cosmic radiation detection (HERD) is a dedicated space cosmic ray detector, planned to be launched and installed on the China Space Station (CSS) around 2027. One of the main goals of HERD is t...
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Article
Four Labdane Diterpenoids from Leonurus japonicus
A new labdane diterpenoid, leojaponotin (1), and three known labdane diterpenoids (2–4), were isolated from Leonurus japonicus. Their structures were elucidated by spectroscopic analysis including NMR and MS.