3 Result(s)
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Article
Wanhe Wang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA small molecule HIF-1α stabilizer that accelerates diabetic wound healing
Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilize...
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Article
Open AccessAnticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction
The hypoxia inducible factor (HIF) pathway has been considered to be an attractive anti-cancer target. One strategy to inhibit HIF activity is through the disruption of the HIF-1α–p300 protein-protein interact...
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Article
Open AccessAntagonizing STAT5B dimerization with an osmium complex
Targeting STAT5 is an appealing therapeutic strategy for the treatment of hematologic malignancies and inflammation. Here, we present the novel osmium(II) complex 1 as the first metal-based inhibitor of STAT5B di...
