Skip to main content

4 Result(s)

within Article Remove this filter Wai Fook Leong Remove this filter English Remove this filter

and

  1. No Access

    Article

    An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients

    Thiopurines are used in the treatment of inflammatory bowel disease (IBD) but remain clinically challenging to manage due to wide interpatient variability in clinical outcomes and adverse events. Apart from ge...

    Sylvia Chen, Wei Zhi Tan, Natalia Sutiman, Cindy Lim… in The Pharmacogenomics Journal (2020)

  2. No Access

    Article

    c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

    Defects in stem cell renewal or progenitor cell expansion underlie ageing-related diseases such as osteoporosis. Yet much remains unclear about the mechanisms regulating progenitor expansion. Here we show that...

    Hui-Yi Kua, Huijuan Liu, Wai Fook Leong, Lili Li, Deyong Jia… in Nature Cell Biology (2012)

  3. No Access

    Article

    A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response

    DNA damage and the elicited cellular response underlie the etiology of tumorigenesis and ageing. Yet, how this response integrates inputs from cells' environmental cues remains underexplored. Here we report th...

    Jenny Fung Ling Chau, Deyong Jia, Zhongfeng Wang, Zhi Liu… in Nature Communications (2012)

  4. No Access

    Article

    Phylogenetic Analysis of Triple Gene Block Viruses Based on the TGB 1 Homolog Gene Indicates a Convergent Evolution

    The complete nucleotide sequence of the triple gene block one (TGB 1) of cymbidium mosaic potexvirus (CymMV) was compared to those from other potex-, carla-, furo- and hordeiviruses. Seven conserved motifs in ...

    Sek-Man Wong, Kian-Chung Lee, Hai-Hui Yu, Wai-Fook Leong in Virus Genes (1998)