16 Result(s)
within
Article
W. **g-Ding
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessA high-density and high-confinement tokamak plasma regime for fusion energy
The tokamak approach, utilizing a toroidal magnetic field configuration to confine a hot plasma, is one of the most promising designs for develo** reactors that can exploit nuclear fusion to generate electri...
-
Article
Root microbiota confers rice resistance to aluminium toxicity and phosphorus deficiency in acidic soils
Aluminium (Al) toxicity impedes crop growth in acidic soils and is considered the second largest abiotic stress after drought for crops worldwide. Despite remarkable progress in understanding Al resistance in ...
-
Article
Open AccessFunction and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor
Advances in structural biology have provided important mechanistic insights into signaling by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is known about intrinsically diso...
-
Article
Open AccessSingle cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons
After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capac...
-
Article
Open AccessCell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function
α-Dystroglycan (α-DG) is uniquely modified on O-mannose sites by a repeating disaccharide (-Xylα1,3-GlcAβ1,3-)n termed matriglycan, which is a receptor for laminin-G domain-containing proteins and employed by old...
-
Article
A preoptic neuronal population controls fever and appetite during sickness
During infection, animals exhibit adaptive changes in physiology and behaviour aimed at increasing survival. Although many causes of infection exist, they trigger similar stereotyped symptoms such as fever, wa...
-
Article
Open AccessCellular anatomy of the mouse primary motor cortex
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integr...
-
Article
Open AccessIntegration of full divertor detachment with improved core confinement for tokamak fusion plasmas
Divertor detachment offers a promising solution to the challenge of plasma-wall interactions for steady-state operation of fusion reactors. Here, we demonstrate the excellent compatibility of actively controll...
-
Article
Open AccessA case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identifi...
-
Article
Open AccessPositron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enh...
-
Article
Open AccessTranscriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons
von Economo neurons (VENs) are bipolar, spindle-shaped neurons restricted to layer 5 of human frontoinsula and anterior cingulate cortex that appear to be selectively vulnerable to neuropsychiatric and neurode...
-
Article
Open AccessPerturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ
Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ ...
-
Article
Open AccessPeriod Increase and Amplitude Distribution of Kink Oscillation of Coronal Loop
Coronal loops exist ubiquitously in the solar atmosphere. These loops puzzle astronomers over half a century. Solar magneto-seismology (SMS) provides a unique way to constrain the physical parameters of corona...
-
Article
Proteogenomics connects somatic mutations to signalling in breast cancer
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe quantitative mass-spec...
-
Article
Open AccessThe transcriptional landscape of age in human peripheral blood
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression met...
-
Article
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
The authors show that the pluripotency factor NANOG interacts with TET1 and TET2 methylcytosine hydroxylases, and that the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine enhances the efficiency o...
