12 Result(s)
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Article
V Cuomo
Biomedicine
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Article
Enduring behavioural and biochemical effects in the adult rat after prolonged postnatal administration of haloperidol
Rats were administered 0.5 mg/kg SC of haloperidol (H) or saline (S) daily from day 1 after birth until 20 days of age. At 60 days of age (40 days after the postnatal treatment with H or S was interrupted) the...
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Early postnatal chlordiazepoxide administration: Permanent behavioural effects in the mature rat and possible involvement of the GABA-benzodiazepine system
The long term behavioural and biochemical effects of chronic chlordiazepoxide treatment during the period of neuronal maturation in the rat have been investigated. The administration to lactating mothers of ch...
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Behavioural and biochemical effects in the adult rat after prolonged postnatal administration of clozapine
Rats were administered 10 mg/kg SC of clozapine (C) or vehicle solution (S) daily from day 1 after birth until 20 days of age. At 60 days of age (40 days after the postnatal treatment with C or S was interrupt...
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Behavioural responsiveness to muscimol and apomorphine 2 months after prolonged treatment with estradiol in rats
Two months after prolonged administration of estradiol (ES) in female rats the behavioural responsiveness to muscimol, a GABA receptor stimulating agent, and to apomorphine, a dopamine receptor agonist, was si...
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Biochemical and behavioral changes in rats after prolonged treatment with desipramine: interaction with p-chlorophenylalanine
The decrease in the B max value of 3H-dihydroalprenolol (3H-DHA) binding to cortical membranes of rat brain induced by long-term administration of desipramine (DMI) was prevented by concomitant treatment with par...
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Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies
The pharmacokinetic behaviour and phototherapeutic effectiveness of bis(di-isobutyloctadecylsil-oxy)-2,3-naphthalocyanatosilicon (iso-BOSiNc) incorporated into dipalmitoyl-phosphatidylcholine (DPPC) liposomes ...
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Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine
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Changes in peripheral nervous system activity produced in rats by prenatal exposure to carbon monoxide
The present experiments were designed to investigate whether alterations of peripheral nervous system activity may be produced in male Wistar rats by prenatal exposure (from day 0 to day 20 of pregnancy) to re...
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In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes
Zinc(II) phthalocyanine, a hydrophobic photosensitiser, was incorporated in unilamellar liposomes and studied in vivo for fluorescence kinetics and photodynamic activity. An observation chamber mounted in a do...
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Lectin binding pattern of schwann cells and macrophages in 2,5-hexanedione-induced axonal degeneration in rats
The lectin binding pattern of both Schwann cells and macrophages has been studied during axonal degeneration induced in the rat sciatic nerve by chronic administration of 2,5-hexanedione (0.8 ml/kg per day i.p...
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Irreversible impairment of active avoidance behavior in rats prenatally exposed to mild concentrations of carbon monoxide
Wistar female rats were exposed to relatively mild concentrations of carbon monoxide (75 and 150 ppm) from day 0 to day 20 of pregnancy. The results show that prenatal exposure to CO (150 ppm) significantly im...
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Cytotoxicity of capsaicin in monkey kidney cells: lack of antagonistic effects of capsazepine and Ruthenium red
Capsaicin is a natural product of Capsicum peppers, excitatory effects of which have been shown to be mediated by the recently cloned vanilloid receptor 1 (VR1). Since previous studies have shown that capsaicin ...
