894 Result(s)
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Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian–human immunodeficiency virus infection
Although maternal human immunodeficiency virus type 1 (HIV-1) transmission occurs during gestation, intrapartum and postpartum (by breast-feeding), 50–70% of all infected children seem to acquire HIV-1 shortly...
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Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma
To study the intravenous and oral pharmacokinetic behavior of oridonin and its extent of absolute oral bioavailability in rats.
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GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth
Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the IAP family members and is r...
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Open AccessAcupuncture as a treatment for functional dyspepsia: design and methods of a randomized controlled trial
Acupuncture is widely used in China to treat functional dyspepsia (FD). However, its effectiveness in the treatment of FD, and whether FD-specific acupoints exist, are controversial. So this study aims to dete...
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Open AccessAccumulation of phenanthrene by roots of intact wheat (Triticum acstivnmL.) seedlings: passive or active uptake?
Polycyclic aromatic hydrocarbons (PAHs) are of particular concern due to their hydrophobic, recalcitrant, persistent, potentially carcinogenic, mutagenic and toxic properties, and their ubiquitous occurrence i...
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Open AccessRole of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters
Cigarette smoking is an important risk factor for pulmonary arterial hypertension (PAH) in chronic obstructive pulmonary disease (COPD). Chymase has been shown to function in the enzymatic production of angiot...
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Erratum to: Recombinant DNA Vaccine Against Inhibition of Neurite Outgrowth Promotes Functional Recovery Associated with Endogeous NGF Expression in Spinal Cord Hemisected Adult Rats
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Open AccessGenome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori
Serine proteases (SPs) and serine proteases homologs (SPHs) are a large group of proteolytic enzymes, with important roles in a variety of physiological processes, such as cell signalling, defense and developm...
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Open AccessCombining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain. ketamine, astrocytic inhibitor and pain
Neuropathic pain is an intractable clinical problem. Intrathecal ketamine, a noncompetitive N--methyl-D-aspartate receptor (NMDAR) antagonist, is reported to be useful for treating neuropathic pain in clinic b...
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Open AccessPrognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma
Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with bo...
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Open AccessThe evolution of vertebrate tetraspanins: gene loss, retention, and massive positive selection after whole genome duplications
The vertebrate tetraspanin family has many features which make it suitable for preserving the imprint of ancient sequence evolution and amenable for phylogenomic analysis. So we believe that an in-depth analys...
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Ambulatory (AASI), but not home (HASI), arterial stiffness index is associated with aortic pulse wave velocity
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Open AccessSeroprevalence of Toxoplasma gondii infection in dairy goats in Shaanxi Province, Northwestern China
Toxoplasma gondii is an important zoonotic pathogen causing significant human and animal health problems. Infection in dairy goats not only results in significant reproductive losses, but also represents an impor...
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Open AccessTest of the τ-model of Bose–Einstein correlations and reconstruction of the source function in hadronic Z-boson decay at LEP
Bose–Einstein correlations of pairs of identical charged pions produced in hadronic Z decays are analyzed in terms of various parametrizations. A good description is achieved using a Lévy stable distribution i...
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Open AccessPerformance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity
The dipstick dye immunoassay (DDIA), recently commercially available in the People's Republic of China (P.R. China), is a rapid and simple test to detect human antibodies against Schistosoma Japonicum. Its perfor...
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Open AccessCharacteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients
Both regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the di...
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Open AccessIndividually integrated traditional chinese medicine approach in the management of knee osteoarthritis: study protocol for a randomized controlled trial
Knee osteoarthritis (OA) is considered a major public health issue causing chronic disability worldwide with the increasing number of aging people. In China and increasingly worldwide, many sufferers with knee...
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Erratum to: Detecting small lung tumors in mouse models by refractive-index microradiology
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Open AccessNeurological abnormalities and neurocognitive functions in healthy elder people: A structural equation modeling analysis
Neurological abnormalities have been reported in normal aging population. However, most of them were limited to extrapyramidal signs and soft signs such as motor coordination and sensory integration have recei...
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Open AccessPreliminary characterization of the oral microbiota of Chinese adults with and without gingivitis
Microbial communities inhabiting human mouth are associated with oral health and disease. Previous studies have indicated the general prevalence of adult gingivitis in China to be high. The aim of this study w...