237 Result(s)
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Article
Ting-**ang Xu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types
C2C12 myoblasts expressing the androgen receptor (AR) were used to analyze the role of androgen-AR signaling pathway in skeletal muscle development. Marked up-regulation of AR expression was observed in different...
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Nitric oxide inhibits ghrelin-induced cell proliferation and ERK1/2 activation in GH3 cells
Ghrelin stimulates growth hormone release and cell proliferation, which strongly supports a significant role for this peptide in the control of growth hormone-releasing adenomas function and growth. Nitric oxi...
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Open AccessAn improved surface-plasmonic nanobeam cavity for higher Q and smaller V
We demonstrate a high-Q hybrid surface-plasmon-polariton-photonic crystal (SP3C) nanobeam cavity. The proposed cavities are analyzed numerically using the three-dimensional finite difference time domain (3D-FDTD)...
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Open AccessPerturbation of mitiglinide metabolism by chronic unpredicted mild stress in rats
Many diabetic patients complicated with wild to severe depression. It is unclear in diabetic medication whether depression perturbs the drug metabolic process of the hypoglycemic agents or not. The present stu...
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Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish
We previously reported a fusion protein NUP98–IQCG in an acute leukaemia, which functions as an aberrant regulator of transcriptional expression, yet the structure and function of IQCG have not been characteri...
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Rapid fabrication of hierarchically structured supramolecular nanocomposite thin films in one minute
Functional nanocomposites containing nanoparticles of different chemical compositions may exhibit new properties to meet demands for advanced technology. It is imperative to simultaneously achieve hierarchical...
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Open AccessMolecular Packing and Electronic Processes in Amorphous-like Polymer Bulk Heterojunction Solar Cells with Fullerene Intercalation
The interpenetrating morphology formed by the electron donor and acceptor materials is critical for the performance of polymer:fullerene bulk heterojunction (BHJ) photovoltaic (PV) cells. In this work we carri...
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Visible-frequency asymmetric transmission devices incorporating a hyperbolic metamaterial
Asymmetric electromagnetic transmission has been recently demonstrated using Lorentz-reciprocal devices, which exploit a variety of patterned structures of linear materials to break spatial inversion symmetry....
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Open AccessBrain Network Informed Subject Community Detection In Early-Onset Schizophrenia
Early-onset schizophrenia (EOS) offers a unique opportunity to study pathophysiological mechanisms and development of schizophrenia. Using 26 drug-naïve, first-episode EOS patients and 25 age- and gender-matched ...
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Open AccessIdentification of a novel salt tolerance gene in wild soybean by whole-genome sequencing
Using a whole-genome-sequencing approach to explore germplasm resources can serve as an important strategy for crop improvement, especially in investigating wild accessions that may contain useful genetic reso...
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Open AccessTLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis
Normal interfollicular epidermis (IFE) homeostasis is maintained throughout the entire life by its own stem cells that self-renew and generate progeny that undergo terminal differentiation. However, the fine m...
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Open AccessThe draft genome of the large yellow croaker reveals well-developed innate immunity
The large yellow croaker, Larimichthys crocea, is one of the most economically important marine fish species endemic to China. Its wild stocks have severely suffered from overfishing, and the aquacultured species...
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Open AccessRILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking
The HOPS complex serves as a tethering complex with GEF activity for Ypt7p in yeast to regulate late endosomal membrane maturation. While the role of HOPS complex is well established in yeast cells, its functi...
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Open AccessAn open science resource for establishing reliability and reproducibility in functional connectomics
Efforts to identify meaningful functional imaging-based biomarkers are limited by the ability to reliably characterize inter-individual differences in human brain function. Although a growing number of connect...
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Open AccessDecelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes
Vertebrates diverged from other chordates ~500 Myr ago and experienced successful innovations and adaptations, but the genomic basis underlying vertebrate origins are not fully understood. Here we suggest, thr...
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A Connectome Computation System for discovery science of brain
Much like genomics, brain connectomics has rapidly become a core component of most national brain projects around the world. Beyond the ambitious aims of these projects, a fundamental challenge is the need for...
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Open AccessSOAX: A software for quantification of 3D biopolymer networks
Filamentous biopolymer networks in cells and tissues are routinely imaged by confocal microscopy. Image analysis methods enable quantitative study of the properties of these curvilinear networks. However, soft...
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Open AccessIntegrin-linked Kinase is Essential for Environmental Enrichment Enhanced Hippocampal Neurogenesis and Memory
Environment enrichment (EE) has a variety of effects on brain structure and function. Brain-derived neurotrophic factor (BDNF) is essential for EE-induced hippocampal neurogenesis and memory enhancement. Howev...
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Open AccessEffect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation
Reactive oxygen species (ROS)-induced oxidative stress in cells is an important pathophysiological process during myocardial ischemia/reperfusion (I/R) injury and the transcription factor Egr-1 is a master swi...
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Open AccessBoth TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs
β-Thalassemia is one of the most common genetic blood diseases and is caused by either point mutations or deletions in the β-globin (HBB) gene. The generation of patient-specific induced pluripotent stem cells (i...
