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Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types

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Abstract

C2C12 myoblasts expressing the androgen receptor (AR) were used to analyze the role of androgen-AR signaling pathway in skeletal muscle development. Marked up-regulation of AR expression was observed in differentiated myotubes. A nuclear run-on transcription assay demonstrated that transcription of the AR gene is increased during skeletal muscle cell differentiation. Regulation of skeletal muscle-specific protein expression by the androgen-AR signaling pathway was further analyzed using quadriceps skeletal muscle from wild-type (WT) and AR knock-out (ARKO) male mice. A histological analysis of quadriceps skeletal muscle indicates no morphological differences between ARKO and WT mice. However, the androgen-AR signaling pathway increases expression of slow-twitch-specific skeletal muscle proteins and downregulates fast-twitch-specific skeletal muscle proteins, resulting in an increase of slow-twitch muscle fiber type cells in quadriceps muscle.

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Change history

  • 02 July 2020

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Authors and Affiliations

  1. George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Cancer Center, University of Rochester Medical Center, 14642, Rochester, New York

    Saleh Altuwaijri, Dong Kun Lee, Kuang-Hsiang Chuang, Huei-Ju Ting, Zhiming Yang, Qingquan Xu, Shuyuan Yeh, LeRoy A. Hanchett & Chawnshang Chang

  2. Department of OB/GYN, Chang Gang University, 833, Kaohsiung, Taiwan

    Meng-Yin Tsai

  3. Department of Urology, National Taiwan University, 100, Taipei, Taiwan

    Hong-Chiang Chang

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  1. Saleh Altuwaijri
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  2. Dong Kun Lee
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  4. Huei-Ju Ting
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  10. Hong-Chiang Chang
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  11. Chawnshang Chang
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Correspondence to Chawnshang Chang.

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Altuwaijri, S., Kun Lee, D., Chuang, KH. et al. Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types. Endocr 25, 27–32 (2004). https://doi.org/10.1385/ENDO:25:1:27

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  • DOI: https://doi.org/10.1385/ENDO:25:1:27

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