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Article
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing
Organization of chromatin structure and regulation of gene transcription are contingent on histone tail modifications. Regions of the genome packaged with nucleosomes that contain methyl histone H3 at lysine 9...
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Article
Characterization of mutations that enhance position-effect variegation in Drosophila melanogaster
Several mutants that enhance the gene inactivation associated with position-effect variegation [E(var) mutants] have been characterized. These include three ethyl methanesulfonate (EMS)-induced lesions and a seco...
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Article
Regulation of dosage compensation in X-chromosomal trisomies of Drosophila melanogaster
In this study, we provide evidence which supports the possibility that dosage compensation in X-chromosomal trisomies (metafemales) can occur by a mechanism distinct from the regulatory system that operates to...
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Article
Genes which suppress position-effect variegation in Drosophila melanogaster are clustered
We have isolated more than 50 dominant suppressors and 3 dominant enhancers of position effect variegation in Drosophila melanogaster. To our surprise, genetic map** studies revealed that the Su(var) mutations ...
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Article
RNA-DNA hybridization analyses of tRNA 3b Val in Drosophila melanogaster
Transfer RNA was extracted from 50–300 mg of adult flies and specifically labeled in vitro. The level of individual isoacceptors was quantitated by efficient annealing to Drosphila tRNA genes carried on recombina...
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Article
Temperature-sensitive mutations in Drosophila melanogaster
Improved methods for rearing and screening large numbers of flies permitted the recovery of 10 mutations exhibiting a reversible temperature-dependent adult paralysis among 1.1×106 flies tested. Of the 10 mutatio...