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  1. No Access

    Article

    Disease System Analysis: Basic Disease Progression Models in Degenerative Disease

    To describe the disease status of degenerative diseases (i.e., type 2 diabetes mellitus, Parkinson’s disease) as function of disease process and treatment effects, a family of disease progression models is int...

    Teun M. Post, Jan I. Freijer, Joost DeJongh, Meindert Danhof in Pharmaceutical Research (2005)

  2. Article

    Open Access

    Extensions to the Visual Predictive Check to facilitate model performance evaluation

    The Visual Predictive Check (VPC) is a valuable and supportive instrument for evaluating model performance. However in its most commonly applied form, the method largely depends on a subjective comparison of t...

    Teun M. Post, Jan I. Freijer… in Journal of Pharmacokinetics and Pharmacody… (2008)

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  3. Article

    Open Access

    Co** with time scales in disease systems analysis: application to bone remodeling

    In this study we demonstrate the added value of mathematical model reduction for characterizing complex dynamic systems using bone remodeling as an example. We show that for the given parameter values, the mec...

    Stephan Schmidt, Teun M. Post… in Journal of Pharmacokinetics and Pharmacody… (2011)

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  4. No Access

    Article

    Application of a mechanism-based disease systems model for osteoporosis to clinical data

    A recently proposed mechanism-based disease systems model for osteoporosis (Schmidt et al., J Pharmacokinet Pharmacodyn 38:873–900, 2011) was applied to clinical data from post-menopausal women (n = 767) receivin...

    Teun M. Post, Stephan Schmidt… in Journal of Pharmacokinetics and Pharmacody… (2013)