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Application of a mechanism-based disease systems model for osteoporosis to clinical data

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  1. Article

    Open Access

    Co** with time scales in disease systems analysis: application to bone remodeling

    In this study we demonstrate the added value of mathematical model reduction for characterizing complex dynamic systems using bone remodeling as an example. We show that for the given parameter values, the mec...

    Stephan Schmidt, Teun M. Post in Journal of Pharmacokinetics and Pharmacody… (2011)

  2. Article

    Open Access

    Extensions to the Visual Predictive Check to facilitate model performance evaluation

    The Visual Predictive Check (VPC) is a valuable and supportive instrument for evaluating model performance. However in its most commonly applied form, the method largely depends on a subjective comparison of t...

    Teun M. Post, Jan I. Freijer in Journal of Pharmacokinetics and Pharmacody… (2008)