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  1. Article

    Open Access

    Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding

    Methods to rapidly generate high quality bispecific antibodies (BsAb) having normal half-lives are critical for therapeutic programs. Here, we identify 3 mutations (T307P, L309Q, and Q311R or “TLQ”) in the Fc ...

    Adam Zwolak, Catherine N. Leettola, Susan H. Tam, Dennis R. Goulet… in Scientific Reports (2017)

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  2. Article

    Open Access

    Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis

    To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs).

    Pamela J. Hornby, Philip R. Cooper, Connie Kliwinski… in Pharmaceutical Research (2014)

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    Article

    Abciximab Pharmacodynamics Are Unaffected by Antecedent Therapy with Other GPIIb/IIIa Antagonists in Non-Human Primates

    Background: Tirofiban and eptifibatide are currently approved for the medical stabilization of non-ST segment elevation acute coronary syndromes. In patients undergoing percutaneous coronary intervention (PCI) d...

    Marian T. Nakada, Patricia M. Sassoli… in Journal of Thrombosis and Thrombolysis (2002)