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  1. Article

    Open Access

    Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks

    Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of cellular processes in diseases such as cancer, although the functions of most remain poorly understood. To address this, here we apply a nov...

    Kevin Walters, Radmir Sarsenov, Wen Siong Too, Roseanna K. Hare… in BMC Genomics (2019)

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  2. Article

    Open Access

    Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway

    Genome-scale RNA-interference (RNAi) screens are becoming ever more common gene discovery tools. However, whilst every screen identifies interacting genes, less attention has been given to how factors such as ...

    Katherine H Fisher, Victoria M Wright, Amy Taylor, Martin P Zeidler… in BMC Genomics (2012)

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  3. No Access

    Article

    Mutations in the pre-replication complex cause Meier-Gorlin syndrome

    Andrew Jackson, Ernie Bongers and colleagues report the identification of mutations in five genes in individuals with Meier-Gorlin syndrome. The five genes, ORC1, ORC4, ORC6, CDT1 and CDC6, all encode components ...

    Louise S Bicknell, Ernie M H F Bongers, Andrea Leitch, Stephen Brown… in Nature Genetics (2011)