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Article
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant diseases 1–4 . Emerging data suggest that the strength and duration of IFN signaling can differentially imp...
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Article
ATP-sensitive potassium channels mediate survival during infection in mammals and insects
Specific homeostatic mechanisms confer stability in innate immune responses, preventing injury or death from infection. Here we identify, from a screen of N-ethyl-N-nitrosourea–mutagenized mice, a mutation causin...
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Article
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
Here we have identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stra...
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Article
CD14 is required for MyD88-independent LPS signaling
The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers. Macrophages from Heedless homozygotes signaled by...