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Article
Juniperus chinensis and the functional compounds, cedrol and widdrol, ameliorate α-melanocyte stimulating hormone-induced melanin formation in B16F10 cells
Anti-melanogenic activities of Juniperus chinensis methanol extracts (JCM) and isolation of functional compounds were investigated. JCM possessed potent anti-oxidative and tyrosinase inhibitory activities. α-Mela...
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Article
Angiotensin converting enzyme inhibitory benzopyranoids from Angelica gigas
Angiotensin converting enzyme (ACE) plays a major role in the regulation of blood pressure. The potential antihypertensive activity of Angelica gigas was evaluated in vitro by its ability to inhibit ACE. A methan...
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Article
Widdrol activates DNA damage checkpoint through the signaling Chk2–p53–Cdc25A–p21–MCM4 pathway in HT29 cells
Widdrol is an odorant compound isolated from Juniperus chinensis. We previously reported that widdrol induces Gap 1 (G1) phase cell cycle arrest and leads to apoptosis in human colon adenocarcinoma HT29 cells. It...
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Article
In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids fromGingko biloba yellow leaves
As part of our research on phytochemicals that exert protective effects against diseases related to reactive nitrogen specie, we have evaluated the scavenging activity of the yellow leaves ofGinkgo biloba on ONOO
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Article
Angiotensin-converting enzyme I inhibitory activity of phlorotannins from Ecklonia stolonifera
As part of our study of the isolation of antihypertensive agents derived from natural marine products, the bioactivity of 10 edible Korean seaweeds were screened by angiotensin converting enzyme (ACE) inhibito...
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Article
Isorhamnetin glycosides with free radical and ONOO− scavenging activities from the stamens ofNelumbo nucifera
In this study, we isolated two new isorhamnetin glycosides, designated as nelumboroside A (3) and nelumboroside B (4), as well as the previously-characterized isorhamnetin glucoside (1) and isorhamnetin rutinosid...
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Article
A phenolic glucoside isolated fromPrunus serrulata var.spontanea and its peroxynitrite scavenging activity
A new phenolic glucoside (1), pursargentoside, was isolated from the leaves ofPrunus serrulata var.spontanea, along with three other known compounds, orobol 7-O-glucoside (2), 1β, 2α, 3α, 24-tetrahydroxy-urs-12-e...
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Article
In Vitro Free Radical and ONOO- Scavengers from Sophora flavescens
Activity-guided fractionation of the CH2CI2-soluble fraction of the roots of Sophora flavescens furnished five 1,1 -diphenyl-2-picrylhydrazyl (DPPH) free radical scavengers: trans-hexadecyl ferulic acid (1), cis-...
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Article
Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells
The antioxidative and hepatoprotective potentials of two anthraquinones, alaternin (2-hydroxy-emodin) and emodin, to scavenge and/or inhibit hydroxyl radicals generated by the Fenton reaction and to protect ta...