131 Result(s)
within
Biochemistry, general
Neurosciences
Si**g Pan
Article
-
Article
The chirality breaking in the photolysis of leucine enantiomers and 5′CMP
The inhibition of the photohydrate formation of the cytidine 5′ monophosphate (5′ CMP) under UV irradiation in the presence of the D-, L-leucine in phosphate aqueous solution (pH 7) has been studied. L-leucine...
-
Article
Transferrin Is an Essential Factor for Myelination
It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists be...
-
Article
Remyelination of the Adult Demyelinated Mouse Brain by Grafted Oligodendrocyte Progenitors and the Effect of B-104 Cografts
The 4e transgenic mouse is characterized by overexpression of the PLP gene. Heterozygous littermates containing three PLP gene copies develop and myelinate normally. However, a progressive CNS demyelination be...
-
Article
Optical Constants of Two Typical Liquid Crystals 5CB and PCH5 in the THz Frequency Range
The complex refractive indices of two benchmark nematic liquid crystal,4-4 ′-n-pentyl-cyanobiphenyl (5CB) and 4-(trans-4′pentylcyclohexyl)-benzonitrile (PCH5) have been determinedin the frequency range from 0.2 t...
-
Article
The Virtual Ventricular Wall: A Tool for Exploring Cardiac Propagation and Arrhythmogenesis
Methods for the experimental and clinical investigation of cardiac arrhythmias are limited to inferring propagation within the myocardium, from surface measurements, or from electrodes at a few sites within th...
-
Article
Down-Regulation of Platelet-Activating Factor Receptor Gene Expression During Focal Reversible Cerebral Ischemia in Rats
Platelet-activating factor (PAF) is an endogenous potent phospholipid mediator in stroke and related to the post-ischemic brain damage. The aim of this study was to investigate the regulation and mechanisms of...
-
Article
Effects of Phenylalanine and its Metabolites on Cytoplasmic Free Calcium in Cortical Neurons
Classic phenylketonuria (PKU) is characterized by brain lesions. However, its underlying neurotoxic mechanisms remain unknown. Based on our previous studies, we hypothesized that calcium might participate in P...
-
Article
A Diffusion Barrier Between the Area Postrema and Nucleus Tractus Solitarius
The blood–brain barrier (BBB) is a structural and functional barrier that prevents free exchange of circulating substances with the brain, where the endothelial cells of microvessels are joined by tight juncti...
-
Article
Cerebral Metabolic Changes in a Depression-like Rat Model of Chronic Forced Swimming Studied by Ex vivo High Resolution 1H Magnetic Resonance Spectroscopy
Many previous in vivo 1H magnetic resonance spectroscopy (MRS) studies have shown that patients with major depressive disorder (MDD) are associated with perturbations of cerebral metabolism of neurotransmitters g...
-
Article
Hippocampal extracellular GABA correlates with metabolism in human epilepsy
As the major inhibitory neurotransmitter in human brain, GABA is an important modulator of hyperexcitability in epilepsy patients. Given the high energetic cost of neurotransmission and synaptic activity, GABA...
-
Article
PMS777, a New Cholinesterase Inhibitor with Anti-Platelet Activated Factor Activity, Regulates Amyloid Precursor Protein Processing In Vitro
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized clinically by progressive impairment of memory and cognition. Previous data have shown that beta-amyloid (Aβ) cascade plays a central role...
-
Article
Combination of G-CSF Administration and Human Amniotic Fluid Mesenchymal Stem Cell Transplantation Promotes Peripheral Nerve Regeneration
Amniotic fluid mesenchymal stem cells (AFS) harbor the potential to improve peripheral nerve injury by inherited neurotrophic factor secretion, but present the drawback of the short-term survival after transpl...
-
Article
Lactacystin Stimulates Stellation of Cultured Rat Cortical Astrocytes
Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Here, the effect of proteasome inhibition on the morphology of cultured rat corti...
-
Article
The association of CaM and Hsp70 regulates S-phase arrest and apoptosis in a spatially and temporally dependent manner in human cells
The cell cycle is controlled by regulators functioning at the right time and at the right place. We have found that calmodulin (CaM) has specific distribution patterns during different cell-cycle stages. Here,...
-
Article
Human Amniotic Fluid Mesenchymal Stem Cells in Combination with Hyperbaric Oxygen Augment Peripheral Nerve Regeneration
Purpose Attenuation of pro-inflammatory cytokines and associated inflammatory cell deposits rescues human amniotic fluid mesenchymal stem cells (AFS) from apoptosis. Hyperbaric oxygen (HBO) suppressed stimulus-in...
-
Article
Nerve Growth Factor of Red Nucleus Involvement in Pain Induced by Spared Nerve Injury of the Rat Sciatic Nerve
Nerve growth factor (NGF), a member of the neurotrophin family, is essential for the development and maintenance of sensory neurons and for the formation of central pain circuitry. The current study was design...
-
Article
The Effects of a Cd81 Null Mutation on Retinal Pigment Epithelium in Mice
The present study examines the effects of Cd81-null mutation on the development of the retinal pigment epithelium (RPE), specifically cell size and number of cells with multiple nuclei. The outlines of RPE in ret...
-
Article
Depletion of Nrf2 Enhances Inflammation Induced by Oxyhemoglobin in Cultured Mice Astrocytes
Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element pathway has been proved to be the key regulator in reducing inflammatory damage, which is involved in subarachnoid hemorrhage (SA...
-
Article
Inhibition of Neuron-Specific CREB Dephosphorylation is Involved in Propofol and Ketamine-Induced Neuroprotection Against Cerebral Ischemic Injuries of Mice
Propofol and ketamine may provide certain degree of neuroprotection, but the underlying mechanism remains unclear to date. The cAMP response element-binding protein (CREB) was proposed that its phosphorylation...
-
Article
Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model
Traumatic brain injury (TBI) results in neuronal apoptosis, autophagic cell death and necroptosis. Necroptosis is a newly discovered caspases-independent programmed necrosis pathway which can be triggered by a...
