70 Result(s)
within
Biomedicine
Antibodies
Si**g Pan
Article
-
Article
Establishment and Characterization of a Cell Based Artificial Antigen-Presenting Cell for Expansion and Activation of CD8+ T Cells Ex Vivo
Artificial antigen-presenting cells are expected to stimulate the expansion and acquisition of optimal therapeutic features of T cells before infusion. Here CD32 that binds to a crystallizable fragment of IgG ...
-
Article
Salmonella Typhi: from a Human Pathogen to a Vaccine Vector
Salmonella (S.) typhi is an important intracellular pathogen. Among the more than 2,300 closely-related Salmonella serovars bacteria recognized, S. typhi is the only one that is pathogenic exclusively for humans,...
-
Article
Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells
Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine rec...
-
Article
CD24: from A to Z
As a testament to the importance of CD24, researchers with diverse interests, including adaptive immunity, inflammation, autoimmune diseases and cancer, have encountered CD24. CD24 is overexpressed in many can...
-
Article
HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1
Melanoma differentiation-associated gene/interleukin-24 (mda-7/IL-24) is a cytokine that can activate monocytes and T helper 2 cells. The expression of mda-7/IL-24 gradually fades with the progression of melan...
-
Article
Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo
Major histocompatibility complex (MHC) class I chain-related protein A (MICA), which is a ligand for human NKG2D, is expressed by a variety of epithelial tumor cells and promotes the activation of natural kill...
-
Article
Optimizing the Efficacy of First-Line Chemotherapy plus Bevacizumab in Metastatic Colorectal Cancer
To assess the efficacy and safety of first-line standard chemotherapy plus bevacizumab in metastatic colorectal cancer and to explore how to optimize therapeutic efficacy.
-
Article
Open AccessHIV-1 Nef compensates for disorganization of the Immunological Synapse by inducing TGN-associated Lck signaling
-
Article
Chimeric flagellin expressed by Salmonella typhimurium induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunization
The flagellin component FliC of Salmonella typhimurium is capable of activating the innate immune system via specific interactions with TLR5 and can also act as a carrier of foreign antigen to elicit antigen-spec...
-
Article
Open AccessCrystal structure analysis of anti-V2 mAb 2158 suggests a conformational epitope involving an N-linked glycan
-
Article
Open AccessStructural analyses of antigen binding similarities and differences between rabbit and human anti-gp120 V3 mAbs
-
Article
Open AccessSequential exposure to specific antibody escape mutations may program neutralization breadth during subtype A HIV-1 infection
-
Article
Open AccessA bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains
Most currently approved anti-HIV drugs (e.g., reverse transcriptase inhibitors, protease inhibitors and fusion/entry inhibitors) must act inside or on surface of the target cell to inhibit HIV infection, but none...
-
Article
Open AccessThe interferon-induced MxB protein inhibits an early step of HIV-1 infection
-
Article
Open AccessFunctional characterization of HIV-1 Nef proteins with heterologous membrane targeting signals
-
Article
Open AccessThe highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB
The human myxovirus-resistance protein B (MxB, also called Mx2) was recently reported to inhibit HIV-1 infection by impeding the nuclear import and integration of viral DNA. However, it is currently unknown wh...
-
Article
Open AccessIn vitro activity of dolutegravir against wild-type and integrase inhibitor-resistant HIV-2
Dolutegravir recently became the third integrase strand transfer inhibitor (INSTI) approved for use in HIV-1–infected individuals. In contrast to the extensive dataset for HIV-1, in vitro studies and clinical ...
-
Article
A novel bovine leukemia virus peptide vaccine targeting susceptible cattle-Estimating vaccine effectiveness using susceptible cattle constructed by fertilized ovum transplantation
-
Article
Amino acids 89–96 of Salmonella typhimurium flagellin represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response
Toll-like receptor 5 (TLR5) signaling in response to flagellin is dispensable for inducing humoral immunity, but alterations of aa 89–96, the TLR5 binding site, significantly reduced the adjuvanticity of flage...
-
Article
The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases
Nuclear receptors play an essential role in cellular environmental sensing, differentiation, development, homeostasis, and metabolism and are thus highly conserved across multiple species. The anti-inflammator...
