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  1. No Access

    Article

    PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions

    C-terminal binding proteins (CtBPs) are cellular corepressors that are targeted by adenovirus E1A. A conserved motif of E1A (PLDLS) interacts with an N-terminal hydrophobic cleft of CtBPs. Many cellular cofact...

    L-J Zhao, T Subramanian, S Vijayalingam, G Chinnadurai in Oncogene (2007)

  2. No Access

    Article

    BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells

    The BH3-only protein BIK normally induces apoptotic cell death. Here, we have investigated the role of BCL-2 in BIK-induced cell death using Bcl-2+/+ and Bcl-2−/− mouse embryo fibroblasts. Ectopic expression of B...

    R Rashmi, S G Pillai, S Vijayalingam, J Ryerse, G Chinnadurai in Oncogene (2008)

  3. No Access

    Article

    BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

    The BNIP3 subfamily of BH3-only proteins consists of BNIP3 and BNIP3-like (BNIP3L) proteins. These proteins form stable homodimerization complexes that localize to the outer membrane of the mitochondria after ...

    G Chinnadurai, S Vijayalingam, S B Gibson in Oncogene (2008)

  4. No Access

    Article

    BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

    BIK is the founding member of the BH3-only family pro-apoptotic proteins. BIK is predominantly localized in the ER and induces apoptosis through the mitochondrial pathway by mobilizing calcium from the ER to t...

    G Chinnadurai, S Vijayalingam, R Rashmi in Oncogene (2008)

  5. Article

    Open Access

    Interaction of ZEB and Histone Deacetylase with the PLDLS-binding cleft region of monomeric C-terminal Binding Protein 2

    Proteins of the C-terminal binding protein (CtBP) family, CtBP1 and CtBP2 are closely related transcriptional regulators that are coded by two different gene loci in the vertebrate genomes. They perform redund...

    Ling-Jun Zhao, M Kuppuswamy, S Vijayalingam, G Chinnadurai in BMC Molecular Biology (2009)

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  6. No Access

    Article

    Evaluation of apoptogenic adenovirus type 5 oncolytic vectors in a Syrian hamster head and neck cancer model

    Human adenovirus (HAdV) vectors are intensely investigated for virotherapy of a wide variety of human cancers. Here, we have evaluated the effect of two apoptogenic HAdV5 vectors in an immunocompetent Syrian h...

    S Vijayalingam, M Kuppuswamy, T Subramanian, F F Strebeck, C L West… in Cancer Gene Therapy (2014)

  7. No Access

    Article

    A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity

    We previously reported a pathogenic de novo p.R342W mutation in the transcriptional corepressor CTBP1 in four independent patients with neurodevelopmental disabilities [1]. Here, we report the clinical phenotypes...

    David B. Beck, T. Subramanian, S. Vijayalingam, Uthayashankar R. Ezekiel… in neurogenetics (2019)