5 Result(s)
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Article
Open AccessGeneration of orthotopic patient-derived xenografts from gastrointestinal stromal tumor
Gastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for develo** targeted anti-cancer therapies. Despite this success, imatinib-resista...
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Article
Open AccessMutaScope: a high-sensitivity variant caller dedicated to high-throughput PCR amplicons sequencing
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Integrating molecular diagnostics into anticancer drug discovery
Efforts to repeat the success of pioneering molecularly targeted cancer drugs, such as trastuzumab, for particular patient populations have been hampered by factors such as a lack of correlation between the mo...
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Article
Gene-target recognition among members of the Myc superfamily and implications for oncogenesis
Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not functionally...
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Article
Identification of differentially regulated gene targets in the Myc and Mad family proteins
