15 Result(s)
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Article
Richard Schwab
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Article
Open AccessA computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial
Precision oncology is currently based on pairing molecularly targeted agents (MTA) to predefined single driver genes or biomarkers. Each tumor harbors a combination of a large number of potential genetic alter...
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Open AccessExploring the landscape of focal amplifications in cancer using AmpliconArchitect
Focal oncogene amplification and rearrangements drive tumor growth and evolution in multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine structure of focally amplified regio...
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Erratum to: Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women
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Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women
To assess tumor subtype distribution and the relative contribution of clinical and sociodemographic factors on breast cancer survival between Hispanic and non-Hispanic whites (NHWs).
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Open AccessMDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients
Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in...
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Open AccessDecreased functional activity of multidrug resistance protein in primary colorectal cancer
The ATP-Binding Cassette (ABC)-transporter MultiDrug Resistance Protein 1 (MDR1) and Multidrug Resistance Related Protein 1 (MRP1) are expressed on the surface of enterocytes, which has led to the belief that ...
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Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospective cohort study
Leptomeningeal metastasis (LM) from solid tumors is typically a late manifestation of systemic cancer with limited survival. Randomized trials comparing single agent intrathecal methotrexate to liposomal cytar...
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Open AccessGeneration of orthotopic patient-derived xenografts from gastrointestinal stromal tumor
Gastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for develo** targeted anti-cancer therapies. Despite this success, imatinib-resista...
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Open AccessMutaScope: a high-sensitivity variant caller dedicated to high-throughput PCR amplicons sequencing
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Integrating molecular diagnostics into anticancer drug discovery
Efforts to repeat the success of pioneering molecularly targeted cancer drugs, such as trastuzumab, for particular patient populations have been hampered by factors such as a lack of correlation between the mo...
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Open AccessMalignant fibrous histiocytoma of the face: report of a case
Soft tissue sarcomas in the head and neck region are rare and often present a difficult differential diagnosis. The aim of our presentation is to point out the complexity of the diagnosis, treatment and follow...
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Open AccessTT-232: An Anti-tumour and Anti-inflammatory Peptide Therapeutic in Clinical Development
TT-232 is a structural derivative of the peptide hormone somatostatin with selective anti-proliferative and anti-inflammatory properties. It has a strong anti-tumour activity both in vitro and in vivo on a wide r...
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Gene-target recognition among members of the Myc superfamily and implications for oncogenesis
Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not functionally...
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Identification of differentially regulated gene targets in the Myc and Mad family proteins
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Effect of endotoxin administration on the severity of acute pancreatitis in two experimental models
Endotoxemia can transform acute pancreatitis (AP) into a more severe form of the disease in models of AP provoked by common pancreatico-biliary duct ligation orl-arginine injection.
