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Article
Open AccessNuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program
Differentiation of cardiac fibroblasts to myofibroblasts is necessary for matrix remodeling and fibrosis in heart failure. We previously reported that mitochondrial calcium signaling drives α-ketoglutarate-dep...
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Article
Open AccessEpigenetic mechanisms regulate sex differences in cardiac reparative functions of bone marrow progenitor cells
Historically, a lower incidence of cardiovascular diseases (CVD) and related deaths in women as compared with men of the same age has been attributed to female sex hormones, particularly estrogen and its recep...
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Article
Open AccessImpact of heart failure on the behavior of human neonatal stem cells in vitro
Clinical cardiac cell therapy using autologous somatic stem cells is restricted by age and disease-associated impairment of stem cell function. Juvenile cells possibly represent a more potent alternative, but ...