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Article
Open AccessCRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements
Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides (ASOs). However, determining promising targets is hampe...
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Article
Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling
Hypoxia and increased levels of inflammatory cytokines in the joints are characteristics of rheumatoid arthritis (RA). However, the effects of hypoxia and tumor necrosis factor-α (TNF-α) on interleukin (IL)-6 ...
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Article
Open AccessOn the force field optimisation of \(\beta\) -lactam cores using the force field Toolkit
When employing molecular dynamics (MD) simulations for computer-aided drug design, the quality of the used force fields is highly important. Here we present reparametrisations of the force fields for the core ...
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Article
Open AccessA paper-based microfluidic platform with shape-memory-polymer-actuated fluid valves for automated multi-step immunoassays
Smart fluid manipulation with automatically controlled paper valves will enable automated and multi-step immunoassays on paper-based microfluidic devices. In this work, we present an integrated paper-based mic...
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Article
Structure and bio-properties of extracellular polysaccharide from Bacillus sp. strain LBP32 Isolated from LUOBOPO desert
A gray and low viscosity extracellular polysaccharide (EPS) composed of N-acetylglucosamine, xylose, and mannose was isolated from culture medium of Bacillus sp. strain LBP32 by ethanol precipitation followed by ...
