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Article
The vibration isolation proprieties of an X-shaped structure with enhanced high-static and low-dynamic stiffness via torsional magnetic negative stiffness mechanism
Bionic X-shaped structure is widely studied for low-frequency vibration isolation. In this paper, an X-shaped structure with torsional magnet negative stiffness (TMNS) mechanisms and torsion springs is propose...
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Article
Open AccessParkin coregulates glutathione metabolism in adult mammalian brain
We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we fir...
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Article
Open AccessAge-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions and that these are refl...
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Article
Open AccessHolocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects
Braak and Del Tredici have proposed that typical Parkinson disease (PD) has its origins in the olfactory bulb and gastrointestinal tract. However, the role of the olfactory system has insufficiently been explo...
