18 Result(s)
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Philip R Jansen
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Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological studies1–5 is mirrored by non-zero, positive genetic correlations from large-scale genetic studies6–10. To identify shared bi...
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Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Cons...
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Open AccessThe phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8
CHD8, a major autism gene, functions in chromatin remodelling and has various roles involving several biological pathways. Therefore, unsurprisingly, previous studies have shown that intellectual developmental di...
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Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associa...
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Open AccessAuthor Correction: Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
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Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we id...
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Open AccessSchizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation
Previous studies have shown that schizophrenia polygenic risk predicts a multitude of mental health problems in the general population. Yet it is unclear by which mechanisms these associations arise. Here, we ...
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Open AccessMultivariate analysis reveals shared genetic architecture of brain morphology and human behavior
Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we...
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Open AccessGenome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
The phenotypic correlation between human intelligence and brain volume (BV) is considerable (r ≈ 0.40), and has been shown to be due to shared genetic factors. To further examine specific genetic factors driving ...
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Open AccessPsychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample
Neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable and influenced by many single nucleotide polymorphisms (SNPs). SNPs ...
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Open AccessGenetic map** and evolutionary analysis of human-expanded cognitive networks
Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical ...
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Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. ...
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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene ...
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Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals
Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intel...
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Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways
Neuroticism is an important risk factor for psychiatric traits, including depression1, anxiety2,3, and schizophrenia4–6. At the time of analysis, previous genome-wide association studies7–12 (GWAS) reported 16 ge...
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3–7, but much about i...
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Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Nat. Genet.; doi:10.1038/ng.3869; corrected online 31 May 2017 In the version of this article initially published online, heritability was misspelled in the penultimate sentence of the abstract. The error has ...
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Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Danielle Posthuma and colleagues perform a large meta-analysis for intelligence and determine genetic overlap with several neuropsychiatric and metabolic traits. They find 15 new significant loci and implicate...
