14 Result(s)
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Peter M. Fischer
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Open AccessA novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin
Although adenosine and its analogues have been assessed in the past as potential drug candidates due to the important role of adenosine in physiology, only little is known about their absorption following oral...
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Web-scale provenance reconstruction of implicit information diffusion on social media
Fast, massive, and viral data diffused on social media affects a large share of the online population, and thus, the (prospective) information diffusion mechanisms behind it are of great interest to researchers. ...
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Open AccessOral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation
Cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoid...
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Development of Cordycepin Formulations for Preclinical and Clinical Studies
There is extensive literature on in vivo studies with cordycepin, but these studies were generally conducted without validation of the various formulations, especially in terms of the solubility of cordycepin in ...
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Disentangling country-of-origin effects: the interplay of product ethnicity, national identity, and consumer ethnocentrism
The country-of-origin (COO) of products has been shown to affect consumer choice, especially in situations where the origin has a stereotypical association with particular products and depending on certain con...
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Internet Corpora: A Challenge for Linguistic Processing
Natural language processing tools are mostly developed for and optimized on newspaper texts, and often show a substantial performance drop when applied to other types of texts such as Twitter feeds, chat data ...
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In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83
Cancer is regarded as a proliferative disorder. Inhibition of cyclin-dependent kinases (CDKs), which are the key regulators of the cell-cycle and RNA transcription, represents an attractive strategy for cancer...
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Editorial
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Schendera, Christian F. G.: Regressionsanalyse mit SPSS
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Turning down tau phosphorylation
Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological inhibition of tau deglycosylation may be a new way to suppre...
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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
Microtubules provide structural support to neurons and microtubule stability is regulated through association with a protein known as tau. Tau is expressed in ...
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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for develop...
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Open AccessPeptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction
Modulation of intracellular protein–protein interactions has been – and remains – a challenging goal for the discovery and development of small-molecule therapeutic agents. Progress in the pharmacological targ...
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Turning the key on p53
The p53 protein is among the most effective of the body's natural defences against cancer. News comes of a promising way of releasing the protein from its inhibitions to carry out its anti-tumour duties.
