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Article
PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway
This study aimed at investigating the role of the proprotein convertase subtilisin/Kexin type 9 (PCSK9)-mediated autophagy on myocardial ischemia/reperfusion injury (MIRI). To determine the relationship betwee...
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Current collapse suppressed GaN diodes with 38 Watts high RF power rectifier capability
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Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes
Osteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identifying mechanisms and biomarkers of osteoporosis will enable the development of preventa...
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Article
Open AccessBulk-local-density-of-state correspondence in topological insulators
In the quest to connect bulk topological quantum numbers to measurable parameters in real materials, current established approaches often necessitate specific conditions, limiting their applicability. Here we ...
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Article
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy
Hypertensive nephropathy (HTN) ranks as the second-leading cause of end-stage renal disease (ESRD). Accumulating evidence suggests that persistent hypertension injures tubular cells, leading to tubulointerstit...
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Article
Open AccessDiscovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the c...
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Cellulase immobilized onto amino-functionalized magnetic Fe3O4@SiO2 nanoparticle for poplar deconstruction
A two-step synthesis method was successfully applied to covalently immobilize cellulase Cellic CTec2 onto silicon dioxide-coated functionalized magnetic nano-Fe3O4 particle (Fe3O4@SiO2). The optimized immobilizat...
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Open AccessSARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread. The nucleic acid-induced stress response is an essenti...
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Identifiable Temporal Feature Selection via Horizontal Visibility Graph Towards Smart Medical Applications
With the proliferation of IoMT (Internet of Medical Things), billions of connected medical devices are constantly producing oceans of time series sensor data, dubbed as time series for short. Considering these...
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Article
Efficient continuous KNN join processing for real-time recommendation
Along with the sustainable and rapid accumulation of user-generated contents in social networking websites, how to push a certain content to the corresponding interested users, named recommendation for short, ...
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Article
Open AccessHazard assessment of oil spills along the main ship** lane in the Red Sea
This study investigates the risk from oil spills along the main ship** lane in the Red Sea based upon oil spill model trajectories forced by the outputs of validated high resolution regional met-ocean data. ...
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Temporal anomaly detection on IIoT-enabled manufacturing
Along with the coming of industry 4.0 era, industrial internet of things (IIoT) plays a vital role in advanced manufacturing. It can not only connect all equipment and applications in manufacturing processes c...
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Article
Higher-order band topology
A conventional topological insulator (TI) has gapped bulk states but gapless edge states. The emergence of the gapless edge states is dictated by the bulk topological invariant of the insulator and the preserv...
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Article
Open AccessThe development of an effective synthetic route of rilpivirine
Rilpivirine (RPV) was approved by the U.S. FDA (Food and Drug Administration) in 2011 to treat individuals infected with human immunodeficiency virus 1 (HIV-1). Significantly, rilpivirine is three fold more po...
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Temporal representation learning for time series classification
Recent years have witnessed the exponential growth of time series data as the popularity of sensing devices and development of IoT techniques; time series classification has been considered as one of the most ...
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SPAR: set-based piecewise aggregate representation for time series anomaly detection
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Open AccessSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected more than 10 million individuals. A typical feature of...
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Article
Open AccessHigher-order quantum spin Hall effect in a photonic crystal
The quantum spin Hall effect lays the foundation for the topologically protected manipulation of waves, but is restricted to one-dimensional-lower boundaries of systems and hence limits the diversity and integ...
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Article
A novel multi-resolution representation for time series sensor data analysis
The evolution of IoT has increased the popularity of all types of sensing devices in a variety of industrial fields and has resulted in enormous growth in the volume of sensor data. Considering the high volume...
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Open AccessTargeting the entry step of SARS-CoV-2: a promising therapeutic approach
