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Article
Copy-number analysis identified new prognostic marker in acute myeloid leukemia
Recent advances in genomic technologies have revolutionized acute myeloid leukemia (AML) understanding by identifying potential novel actionable genomic alterations. Consequently, current risk stratification a...
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Article
CDC25A targeting by miR-483-3p decreases CCND–CDK4/6 assembly and contributes to cell cycle arrest
Disruption of contact inhibition and serum afflux that occur after a tissue injury activate cell cycle, which then stops when confluence is reached again. Although the events involved in cell cycle entry have ...
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Article
Open AccessMiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
The resistance of hypoxic cells to radiotherapy and chemotherapy is a major problem in the treatment of cancer. Recently, an additional mode of hypoxia-inducible factor (HIF)-dependent transcriptional regulati...
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Article
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
Following the identification of a set of hypoxia-regulated microRNAs (miRNAs), recent studies have highlighted the importance of miR-210 and of its transcriptional regulation by the transcription factor hypoxi...
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Article
Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers
Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly...
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Article
miR-34b/miR-34c: a regulator of TCL1 expression in 11q− chronic lymphocytic leukaemia?
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Article
Open AccessP1.58 Abnormal Vascular Fetal Programming in Rats Subjected to Maternal Diabetes
Epidemiologic studies have clearly identified modifications of fetal environment as a risk factor for the development of cardiovascular diseases in adulthood.
