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Article
Open AccessMethodological study of affine transformations of gene expression data with proposed robust non-parametric multi-dimensional normalization method
Low-level processing and normalization of microarray data are most important steps in microarray analysis, which have profound impact on downstream analysis. Multiple methods have been suggested to date, but i...
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Article
Open AccessThe genetic interacting landscape of 63 candidate genes in Major Depressive Disorder: an explorative study
Genetic contributions to major depressive disorder (MDD) are thought to result from multiple genes interacting with each other. Different procedures have been proposed to detect such interactions. Which approa...
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Article
Open AccessA significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis
The genetic background to bipolar disorder (BPD) has been attributed to different genetic and genomic risk factors. In the present study we hypothesized that inherited copy number variations (CNVs) contribute ...