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G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

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  1. Article

    Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Signe Mathiasen, Tiago Palmisano, Nicole A. Perry… in Nature Chemical Biology (2020)

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  2. Article

    Open Access

    Structural basis of arrestin-3 activation and signaling

    A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and...

    Qiuyan Chen, Nicole A. Perry, Sergey A. Vishnivetskiy… in Nature Communications (2017)

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  3. Article

    Open Access

    β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

    β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation o...

    Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto… in Nature Communications (2017)

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  4. Article

    Open Access

    Peptide mini-scaffold facilitates JNK3 activation in cells

    Three-kinase mitogen-activated protein kinase (MAPK) signaling cascades are present in virtually all eukaryotic cells. MAPK cascades are organized by scaffold proteins, which assemble cognate kinases into prod...

    Xuanzhi Zhan, Henriette Stoy, Tamer S. Kaoud, Nicole A. Perry… in Scientific Reports (2016)

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