3 Result(s)
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Article
Nicole A. Perry
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessStructural basis of arrestin-3 activation and signaling
A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and...
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Article
Open Accessβ-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation o...
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Article
Open AccessPeptide mini-scaffold facilitates JNK3 activation in cells
Three-kinase mitogen-activated protein kinase (MAPK) signaling cascades are present in virtually all eukaryotic cells. MAPK cascades are organized by scaffold proteins, which assemble cognate kinases into prod...
